Involvement of adenosine receptors with inhalation anesthetics
- Conditions
- Healthy adult
- Registration Number
- JPRN-jRCTs041190124
- Lead Sponsor
- Sakurai Satoru
- Brief Summary
Adenosine receptor stimulation was suggested to cause side effects such as chest discomfort and headache. The combined administration of ATP formulation during general anesthesia with sevoflurane does not cause serious complications and is highly safe. However, the result of this study suggest that the anesthetic (hypnotic) action of sevoflurane was antagonized by adenosine receptors. Since the mechanism is unknown, it is necessary to study further in the future to elucidate it.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 11
1. Healthy adult men aged 20 to 39
2. Consent for study participation was obtained by signing consent form for this study
1. Person who may cause airway obstruction (e.g.: obesity, sleep apnea syndrome)
2. Person who have previously used a halogenated anesthetic and have jaundice or an unexplained fever
3. Person with a history of hypersensitivity to sevoflurane
4. Person taking psychotropic drugs (including taking sleeping pills)
5. Person with serious liver disorder, kidney disorder, respiratory disease, heart disease
6. Person who is judged unqualified by the study responsible dentist or the study dentist
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depth of anesthesia (BIS)
- Secondary Outcome Measures
Name Time Method Directed behavior, cognitive ability, psychomotor function, balanced motor function, circulation (heart rate, blood pressure, electrocardiogram), breathing (respiration rate, tidal volume, end-tidal carbon dioxide concentration, SpO2), and safety