Relationship Between Postoperative Cognitive Decline and Cytokines in Elderly Patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Cognitive Decline
- Sponsor
- Jia-feng Wang
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Differences in cytokines levels between the two groups
- Last Updated
- 7 years ago
Overview
Brief Summary
postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1，SOD2，Osteopontin， Kallikrein-6，and Contactin-1 and postoperative cognitive decline is unknown. In this project ,investigators examine the relationship between 5 cytokines measured at there timepoints (preoperative [PREOP], postoperative day 1 [POD1] , and postoperative day 3[POD2]) and postoperative cognitive decline among older adults undergoing orthopedic surgery.
Investigators
Jia-feng Wang
M.D
Changhai Hospital
Eligibility Criteria
Inclusion Criteria
- •patients who are more than 65 years old
- •patients who undergo orthopedic surgery(trauma ,especially fracture of lower limb)
- •patients with ASA physical status I-III
- •patients who have a consent
Exclusion Criteria
- •patients who are more than 85 years old
- •patients with ASA physical status \>III
- •patients who have neurological disorders, stroke or other affective central nervous system diseases
- •patients who have a history of serious psychiatric illness
- •patients with long-term use of psychoactive substances
- •patients who undergo multiple trauma and the presence of head injury
Outcomes
Primary Outcomes
Differences in cytokines levels between the two groups
Time Frame: 72h after operation
Compare differences in cytokines levels between the two groups