Study of Postoperative Cognitive Decline in Aged Patients
- Conditions
- Cognitive Decline
- Registration Number
- NCT03765840
- Lead Sponsor
- Jia-feng Wang
- Brief Summary
postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1，SOD2，Osteopontin， Kallikrein-6，and Contactin-1 and postoperative cognitive decline is unknown. In this project ,investigators examine the relationship between 5 cytokines measured at there timepoints (preoperative \[PREOP\], postoperative day 1 \[POD1\] , and postoperative day 3\[POD2\]) and postoperative cognitive decline among older adults undergoing orthopedic surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
- patients who are more than 65 years old
- patients who undergo orthopedic surgery(trauma ,especially fracture of lower limb)
- patients with ASA physical status I-III
- patients who have a consent
Exclusion Criteria
- patients who are more than 85 years old
- patients with ASA physical status >III
- patients who have neurological disorders, stroke or other affective central nervous system diseases
- patients who have a history of serious psychiatric illness
- patients with long-term use of psychoactive substances
- patients who undergo multiple trauma and the presence of head injury
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in cytokines levels between the two groups 72h after operation Compare differences in cytokines levels between the two groups
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Deartment of anesthesiology,changhai hospital
🇨🇳Shanghai, Shanghai, China