Immunology of endometrium in heavy menstrual bleeding
Not Applicable
- Conditions
- Health Condition 1: N920- Excessive and frequent menstruation with regular cycle
- Registration Number
- CTRI/2024/05/067502
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All women visiting obstetrics and gynecology OPD in AIIMS Bibinaga with heavy menstrual bleeding without a structural cause.
Exclusion Criteria
1)Samples displaying evidence of hyperplasia or atypia on microscopic evaluation.
2)Samples with tissue that are inadequate for further immunohistochemical evaluation
3)Patients with pelvic inflammatory disease or any other conditions affecting the immunity like autoimmune diseases.
4)Patients on immune modifying drugs.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the alterations in the number of uterine natural killer cells, T cells and macrophages in the endometrial biopsy specimens of women with normal menstrual cycles and those with heavy menstrual bleeding.Timepoint: At the time of Endometrial biopsy.
- Secondary Outcome Measures
Name Time Method To compare the expression of immunohistochemistry in uterine natural killer cells, T cells and macrophages in the endometrial biopsy specimens of women with heavy menstrual bleeding and correlate this with the severity of clinical symptoms in patients with HMB.Timepoint: On histopathology slides after endometrial biopsy