Carnitine status in fit and pre-frail/frail elderly compared to healthy young individuals
- Conditions
- Elderly, Frailty, Carnitine, Mitochondrial dysfunctionOuderen, Kwetsbaarheid, Carnitine, Mitochondriale dysfunctie
- Registration Number
- NL-OMON26053
- Lead Sponsor
- VHL University of Applied ScienceDr. Feike van der LeijFood & Dairy Applied Research Centre PO Box 1528, 8901 BV LeeuwardenE-mail: feike.vanderleij@hvhl.nl
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 78
Inclusion Criteria
Healthy young subjects
- 20-30 years of age
Exclusion Criteria
- Contra-indication for DEXA-scan, e.g. metal splinters
- Contra-indication for muscle biopsy, e.g. use of anticoagulants.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intramuscular carnitine levels and carnitine derivatives
- Secondary Outcome Measures
Name Time Method Carnitine status and its derivatives in<br>PBMCs<br /><br>Mitochondrial function in muscle tissue<br>and PBMCs<br /><br>Fat and fat-free mass<br /><br>Plasma carnitine and its derivatives<br /><br>Short Physical Performance Battery<br>(SPPB)<br /><br>400m walk time<br /><br>Cognitive function