Anorexia Nervosa and it's Effects on Brain Function, Body Metabolism and Their Interaction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anorexia Nervosa
- Sponsor
- Turku University Hospital
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Changes in brain reward system and metabolism in AN patients
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The neuromolecular and metabolic underpinnings of Anorexia Nervosa (AN) are studied using multi-modal molecular (positron emission tomography with two different radioligands) and functional (functional magnetic resonance imaging) neuroimaging in a prospective design. Subjects with AN and normal weight adolescents will be studied with PET and MRI and followed for five years.
Detailed Description
A total of sixty females (30 with AN, 30 healthy controls) are recruited into this prospective study. The subjects will undergo physical examination, body tissue composition measurement, functional and structural MRI of the brain and body, and positron emission tomography (PET) with ligands \[18F\]-FDG, and \[11C\]carfentanil. Subjects' weight and physical condition will be followed up for 5 years. The study will start in August 2020 and end in the fall of 2028.
Investigators
Pirjo Nuutila
Principal Investigator
Turku University Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Any chronic disease or medication that could affect glucose metabolism or neurotransmission
- •History of psychiatric disorders (excl. AN for the corresponding study group)
- •Smoking of tobacco, taking of snuffs, or use of narcotics
- •Abusive use of alcohol
Outcomes
Primary Outcomes
Changes in brain reward system and metabolism in AN patients
Time Frame: 10 years
AN patients and controls are studied using fMRI and PET imaging and followed 10 years. Reward system function is measured using functional MRI and metabolism using 18F-fluorodeoxy glucose and PETCT imaging
Predictive value of baseline body mass index (BMI), functional brain activation and metabolism in AN
Time Frame: 10 y
Results from baseline are combined with follow updata