Comparison of N-acetyl cysteine (NAC) and placebo in craving reduction in methamphetamine dependent subjects

Isfahan University of Medical Sciences, Behavioral Sciences Research Center0 个研究点目标入组 30 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•1) men and women aged 18–65 years old; 2) informed acceptance to comply with study procedures. Exclusion criteria: 1) sever medical illness that would impair the ability to participate safely in the study; 2) a current neurological or axis I psychiatric disorders not due to substance abuse (e.g., schizophrenia, dementia) that would impair ability to participate safely in the study; 3) current pregnancy or nursing in women; 4) current serious suicidal intention or plan; 5) more than 3 times elevation of AST and ALT at screening; 6) past medical history of asthma or seizures; 7) Subjects who had recently used medications (<14 days) felt to be hazardous if taken with NAC (e.g. carbamazepine, nitroglycerin); and 8) subjects who met DSM-IV criteria for opiates dependence. Also in following conditions the patient will be out of study: 1) incidence of seizure or sever medical illness that would impair ability to participate safely in the study; 2) non compliance or not willing for continuing the study; 3) sever and unbearable drug side effect even after reducing the dose.

发起方

Isfahan University of Medical Sciences, Behavioral Sciences Research Center