Effects of Different Losartan Combination Antihypertensive Therapy in CKD Patients
- Conditions
- Chronic kidney disease patients complicated with hypertension
- Registration Number
- JPRN-UMIN000004062
- Lead Sponsor
- agoya University CKD Clinical Cooperation System Study Group
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 120
Not provided
1. Patients whose serum creatinine was 2 mg/dL or greater within three months or patients whose eGFR were less than 30 mL/min/1.73 m2 before the informed consent acquisition 2. Patients whose hepatic function was over 3 times higher than normal upper limit within three months before the informed consent acquisition 3. Patients whose HbA1c was more than 8.0 within three months before the informed consent acquisition 4. Patients received hospitalizing by onset of cardiovascular disease, myocardial infarction, cerebral apoplexy, cardiac insufficiency within six months before the informed consent acquisition 5. Patients complicated angina pectoris, cardiac insufficiency with NYHA 3 or greater at the informed consent acquisition 6. Patients who is already prescribed diuretic or Ca antagonist at the informed consent acquisition 7. Patients with poor feeding 8. Patients of remarkable emaciation 9. Patients complicated with nephrotic syndrome 10. Patients judged unsuitable by physician in charge
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method rinary albumin excretion from 0 to 3 months between 2 groups
- Secondary Outcome Measures
Name Time Method A. Following parameters from 0 to 3 months between 2 groups; 1. Systolic and diastolic blood pressure 2. BNP 3. HOMA-beta and HOMA-IR 4. hs-CRP 5. eGFR 6. Urinnary sodium excretion 7. Serum K 8. HbA1c 9. Serum uric acid 10.Pulse wave velocity(PWV):optional B. Following parameters from 0 to 6 months between 2 groups; 1. Urinary albumin excretionin 2. Serum K 3. HbA1c 4. Serum urin acid