Differences and similarities in auditory hallucinations in healthy subjects and in patients with different psychiatric diagnoses.

Completed

• Conditions: auditory verbal hallucinations; hearing voices; 10039628

• Registration Number: NL-OMON30169
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

General inclusion criteria:
- age > 18 years
- has experienced auditory verbal hallucinations at least once within the last three months.;Phenomenology:
-healthy subjects
-patients with schizophrenia
-patients with personality disorder
-patients with bipolar disorder
-patients with unipolar depression.;Specific inclusion criteria for brain imaging:
- frequent hallucinations, at least 4 bouts per hour

Exclusion Criteria

General exclusion criteria:
- age < 18 years
Exclusion for the fMRI part:
- methal objects in or around the body that cannot be removed
-pregnancy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Phenomenology: The differences and resemblance in the phenomenology of AVH<br /><br>between the different groups<br /><br>-Genotyping: associations of AVH with genes or genetic regions (by searching<br /><br>the whole genome).<br /><br>- Brain imaging: fMRI: activation maps of language-related and<br /><br>hallucination-related activity will be compared between the different groups.<br /><br>DTI: connectivity between the activated brain areas will be assessed and<br /><br>compared. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>no secundary parameters</p><br>