Causes, Complications and Outcomes of Severe Acute Liver Disease Cases Admitted to Intensive Care Units
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 主要终点
- Assessment of Liver function in individuals with ALF admitted to intensive care unit.
研究概览
简要总结
Acute liver failure (ALF) is a potentially fatal complication of severe hepatic illness resulting from various causes. In a clinical setting, severe hepatic injury is usually recognized by the appearance of jaundice, encephalopathy and coagulopathy.
The term acute liver failure (ALF) is frequently applied as a generic expression to describe patients presenting with or developing an acute episode of liver dysfunction.
Cerebral edema is very common in patients with acute liver failure and encephalopathy.
Acute liver failure (ALF) has Less common aetiologies include viral hepatitis, drug-induced liver injury, pregnancy-induced liver failure and autoimmune hepatitis.
Survival for patients with ALF has steadily improved over the last few decades. Acute liver failure (ALF) is defined as sever acute liver injury with encephalopathy and impairment of synthetic function (INR ˃1.5) in a patient without pre-existing cirrhosis or liver disease.
Acute liver failure (ALF) and acute on chronic liver Failure (ACLF) are conditions frequently encountered in the ICU and are associated with high mortality.
详细描述
The main objectives of this observational study are:
- To evaluate cases of (ALF) and (ACLF) according to guidelines.
- To determine most likely causes of disease in a patient of each age.
- To determine complications of disease.
- Assesment of mortality and morbidity rates.
- Assessment of in-hospital and six month follow up outcomes according to guidelines.
Participants (or their designated contact persons) will be contacted over the phone for either a telephone interview or a follow-up visit in the outpatient clinics, whichever feasible and possible.
All patients presented with severe acute liver disease, acute liver failure (ALF) and acute on chronic liver disease (ACLF).
- Inclusion criteria:
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •reduced conscious state
- •Jaundice with abnormal liver function tests, especially elevations in amino acid transferase levels more than 25 times the upper limit of normal
- •Coagulopathy
- •Multiorgan failure
排除标准
- •Patients with known cardiac cirrhosis.
- •Patients with known pre-existing renal disease
结局指标
主要结局
Assessment of Liver function in individuals with ALF admitted to intensive care unit.
时间窗: 2 weeks after admission to intensive care unit
Measuring serum alanine transaminase (ALT) level, serum aspartate transaminase (AST) level, serum alkaline phosphatase (ALP) level, serum gamma-glutamyl transferase (GGT) level.
Assessment of fluid overload in individuals with ALF admitted to intensive care unit.
时间窗: 2 weeks after admission to intensive care unit
Measuring body weight.
Assessment of kidney function in individuals with ALF admitted to intensive care unit.
时间窗: 2 weeks after admission to intensive care unit
Measuring serum creatinine level
次要结局
- Mortality rates(2 weeks after admission to intensive care unit)
- Morbidity rates(2 weeks after admission to intensive care unit)
研究者
Abdallah Hussein Kamel Ibrahim
Resident Physician
Assiut University