Investigation of the Duration of Low-intensity Focused Ultrasound
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Waveforms
研究概览
简要总结
This project examines the effects of various durations of noninvasive neuromodulation on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, a functional Magnetic Resonance Image (fMRI) and computed tomography (CT). These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions of the hand.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Above criteria and must understand and speak English.
排除标准
- •Contraindications to MRI, CT, or TMS
- •Claustrophobia
- •Pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
- •Active medical disorder or treatment with potential CNS effects
- •History of neurologic disorder
- •History of head injury resulting in loss of consciousness for >10 minutes
- •History of alcohol or drug dependence
研究组 & 干预措施
Duration Trials
Six different durations (three intermittent and three continuous) of LIFU application will be tested across six study sessions. Response recorded using TMS and EMG.
干预措施: Low-Intensity Focused Ultrasound (Device)
结局指标
主要结局
Waveforms
时间窗: Outcomes assessed throughout participation - an average of 3 weeks.
Changes in waveform peak will be observed per each variable application of LIFU
次要结局
未报告次要终点
研究者
Wynn Legon
Assistant Professor
Virginia Polytechnic Institute and State University