Markers in the Diagnosis of TIA
试验速览
- 阶段
- 不适用
- 发起方
- UMC Utrecht
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- 'Definite' Diagnosis of TIA
研究概览
简要总结
MIND-TIA is primarily an observational diagnostic study that aims to evaluate the role of novel biomarkers in the diagnosis of Transient Ischemic Attack (TIA)in primary care.
Rapid and adequate diagnosis of TIA is of great importance to enable a rapid start of treatment, and thereby decrease the risk of subsequent ischemic stroke.
详细描述
Rationale:
A Transient Ischaemic Attack (TIA) does not cause permanent damage of brain tissue, but the risk of a subsequent ischemic stroke in the short term is high. Timely recognition of TIA would result in early treatment and reduce the risk of ischaemic stroke, and other adverse cardiovascular events.
To improve the management of TIA adequate diagnosis is of imminent importance. However the diagnosis is notoriously difficult, for both GP and neurologist.
Adequate biomarkers for brain ischaemia could improve the early diagnosis and thus the subsequent management of TIA.
Objectives:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Being adult (18 years and older)
- •Presenting to the GP with a new episode of symptoms suspected of TIA and the GP considering further investigations to confirm or exclude TIA at the TIA outpatient clinic.
- •A blood sample can be collected within 72 hours after onset of symptoms.
排除标准
- •The patient still has active symptoms or signs suspected of an ongoing ischemic stroke and immediate referral to the neurologist seems indicated.
- •Valid history taking is impossible because of severe cognitive impairment or insufficient knowledge of the Dutch language.
- •Patient with a life expectancy of < 6 months.
- •Patient is not willing or able to give written informed consent
结局指标
主要结局
'Definite' Diagnosis of TIA
时间窗: After 6 months of follow-up
Determined by expert panel consisting of 3 neurologists
次要结局
- Ischemic stroke and other cardiovascular events(During 6 months of follow-up)
- Time delay to GP consultation and start of treatment(1 day of home visit)