A study to evaluate outcomes after Early versus Late initiation of Continuous Renal Replacement Therapy in critically ill adult patients

Early CRRT group

Patients receiving CRRT at KDIGO Stage II AKI (Patients developing Acute Kidney Injury During the ICU stay) will be designated as early CRRT group. A maximum of 8 hours is allowed between clinical decision regarding initiating CRRT and the actual initiation of CRRT.

Delayed CRRT group

Patients not receiving CRRT at AKI Stage II or patients getting admitted in ICU with diagnosed Chronic Kidney Disease included in the delayed CRRT group

AIM

To evaluate 28- day mortality and renal recovery rate after Early versus Late initiation of Continuous Renal replacement therapy in Critically ill Adult patients

Primary Objective

·       To compare 28-day mortality among critically ill patients with early versus late initiation of Continuous Renal Replacement Therapy

 Secondary Objective

·       To compare renal recovery rate among critically ill patients with early versus late initiation of Continuous Renal Replacement Therapy

·       To study the length of stay in Intensive Care Unit and hospital

Total sample Size is 32

INCLUSION CRITERIA

1.   Consenting adults aged between 20 to 65 years

2.   Patients compatible with the diagnosis of AKI at stage 2 of KDIGO classification.

3.   More than two fold increase of Serum creatinine level compared with the baseline value and/or urine output less than 0.5ml/kg/hour for 12 hours

Exclusion criteria

1.   Declined consent from guardian

2.   Pre-existing severe chronic renal failure (estimated Glomerular Filtration rate less than 30 ml/min)

3.   Previous RRT