Vertical Ridge Augmentation Using Computer-guided Sandwich Osteotomy Technique

Phase 1

Active, not recruiting

• Conditions: Alveolar Bone Resorption
• Interventions: Procedure: Sandwich technique with xenograft, collagen membrane and simultaneous implant placement.; Biological: Sandwich technique with (RGD), xenograft, collagen membrane and simultaneous implant placement.

• Registration Number: NCT07028606
• Lead Sponsor: Al-Azhar University

Brief Summary

Researcher will introduce the trial to patients and provide full explanation of its aim and benefits in Arabic language. Patients will then be able to have an informed discussion with the researcher. Researcher will obtain written consent from patients willing to participate in the trial

Detailed Description

This protocol and the template informed consent form will be reviewed by the Ethics Committee of Scientific Research -Faculty of Oral and Dental Medicine- Al-Azhar University.

Study Timeline

• Study Start: 2024-05-09
• Study First Submitted: 2025-04-17
• Primary Completion: 2025-05-10
• Status Verified: 2025-06
• Study Completion: 2025-06-10
• Study First Submitted QC: 2025-06-11
• Last Update Submitted: 2025-06-11
• Study First Posted: 2025-06-19
• Last Update Posted: 2025-06-19

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Sandwich technique with xenograft, collagen membrane and simultaneous implant placement	Sandwich technique with xenograft, collagen membrane and simultaneous implant placement.	(Control group) will receive computer-guided sandwich osteotomy technique with xenograft, collagen membrane and simultaneous implant placement.
Sandwich technique with (RGD), xenograft, collagen membrane and simultaneous implant placement	Sandwich technique with (RGD), xenograft, collagen membrane and simultaneous implant placement.	(Study group) will receive computer-guided sandwich osteotomy technique with (RGD), xenograft, collagen membrane and simultaneous implant placement.

Primary Outcome Measures

Name	Time	Method
Effect of RGD on volumetric bone changes	Preoperative Cone beam computed tomography (CBCT) with minimal field of view will be taken for (implant treatment plan), immediately after surgery, at time of loading and 6 months after loading.	Cone beam computed tomography with minimal field of view was taken immediately after surgery, immediately before loading (6 months) and 6 months after loading to evaluate volumetric changes.

Trial Locations

Locations (1)

Al-Azhar University, Cairo, Boys; 🇪🇬 Cairo, Nasr City, Egypt