Volume Kinetics of Fluid Resuscitation in Early Sepsis
- Conditions
- Fluid and Electrolyte Imbalance
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria:<br><br>A diagnosis of sepsis, as defined by the Sepsis-3 criteria and exhibiting sepsis-induced<br>hypoperfusion prior to the administration of adequate volume resuscitation:<br><br> - hypotension requiring norepinephrine to maintain a mean arterial blood pressure<br> (MAP) either predefined by the clinician or at 65 mm Hg or higher and/or<br><br> - a serum lactate level >2 mmol/L (18mg/dL) and/or<br><br> - acute oliguria defined as urine output <0.5mL/kg/hr and/or<br><br> - mottled skin and/or<br><br> - capillary refill time > 3 seconds.<br><br>Exclusion Criteria:<br><br> - Administration of at least 1 L of IV fluid in the last 6 hours prior to screening.<br> All crystalloids, colloids and blood products that the patient has received are<br> counted.<br><br> - Known pregnancy.<br><br> - Competing causes of lactic acidosis including: seizures within 3 hours of<br> enrollment, use of linezolid or metformin or anti-retrovirals at the time of<br> enrollment, carbon monoxide or cyanide poisoning, highly suspected or known ischemic<br> bowel, and known mitochondrial disorders.<br><br> - End-stage renal disease that requires chronic dialysis.<br><br> - Concurrent haemorrhagic or obstructive shock.<br><br> - Increased risk of fluid intolerance:<br><br> - Echocardiographic evidence of moderate or severe left ventricular systolic<br> dysfunction.<br><br> - Echocardiographic evidence of moderate or severe right ventricular systolic<br> dysfunction.<br><br> - Hypoxemia index < 200 mmHg or sonographic evidence of bilateral B or C profile.<br><br> - Abdominal compartment syndrome.<br><br> - Post-cardiac arrest.
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma Volume
- Secondary Outcome Measures
Name Time Method