The effect of N-Acetylcysteine on red blood cell transfusion burden in transfusion dependent Beta thalassemia children A open labelled experimental study

Two to twelve years old Beta thalassemia children on regular blood transfusion and iron chelation will be considered for the study.After applying the inclusion and exclusion criteria and obtaining informed written consent from the parents,children will be enrolled as study group.Baseline characteristics,mean pretransfusion Hb,LFT,Serum ferritin,transfusion volume over the last three months will be recorded.NAC will be administered at a dose of 10mg/kg/day.At their regular follow up(3 to 4weeks interval),per transfusion Hb and volume of transfusion will be noted.At the end of three months,mean per transfusion Hb,volume of transfusion over last three months and Serum ferritin will be noted.Statistical association will be analysed using paired t test.p value less than 0.05 will be considered significant .

Durin the study period,patients will be called over telephone everyday for the initial two weeks and weekly once thereafter to ensure compliance and also address their concerns if any.Empty tablet blisters will be checked at regular follow up.