IRCT20120703010178N15招募中未知
Comparison of safety and effectiveness of Levofloxacin/Colistin regimen with Levofloxacin/high dose Ampicillin-sulbactam infusion in treatment of Ventilator-Associated Pneumonia due to multi drug resistant Acinetobacter
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 56
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 no limit（—）
- 性别
- All
入选标准
- •Participant has received mechanical ventilation for > 48 hours
- •Acute Physiology and Chronic Health Evaluation (APACHE) II score of more than 8
- •CPIS score >6
- •ETT culture of MDR acinetobacter (‘MDR Acinetobacter spp.’ will be defined as the isolate resistant to at least three classes of antimicrobial agents as below:all penicillins and cephalosporins (including inhibitor combinations), fluroquinolones, and aminoglycosides.)
排除标准
- •History of moderate or severe hypersensitivity reactions to beta-lactam antibiotics or colistin
- •Kidney injury defined as GFR<30ml/min (day 0 to 3 of the study)
- •Have received antibiotics for this episode of ventilator-associated pneumonia for more than 96 hours before study medication administration
- •co-infection in another organs
- •Acute respiratory distress syndrome
- •Has any of the following conditions: chest trauma with a fracture of the sternum, ribs, or both
- •Has lung cancer within the last 2 years
- •chronic bronchitis with an increase in severity within the last 30 days
- •tuberculosis on treatment
- •suspected atypical pneumonia
- •cystic fibrosis and severe burns to greater than 15% of the body
研究者
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