IRCT20120703010178N15
Recruiting
未知
Comparison of safety and effectiveness of Levofloxacin/Colistin regimen with Levofloxacin/high dose Ampicillin-sulbactam infusion in treatment of Ventilator-Associated Pneumonia due to multi drug resistant Acinetobacter
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Shahid Beheshti University of Medical Sciences
- Enrollment
- 56
- Status
- Recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Participant has received mechanical ventilation for \> 48 hours
- •Acute Physiology and Chronic Health Evaluation (APACHE) II score of more than 8
- •CPIS score \>6
- •ETT culture of MDR acinetobacter (‘MDR Acinetobacter spp.’ will be defined as the isolate resistant to at least three classes of antimicrobial agents as below:all penicillins and cephalosporins (including inhibitor combinations), fluroquinolones, and aminoglycosides.)
Exclusion Criteria
- •History of moderate or severe hypersensitivity reactions to beta\-lactam antibiotics or colistin
- •Kidney injury defined as GFR\<30ml/min (day 0 to 3 of the study)
- •Have received antibiotics for this episode of ventilator\-associated pneumonia for more than 96 hours before study medication administration
- •co\-infection in another organs
- •Acute respiratory distress syndrome
- •Has any of the following conditions: chest trauma with a fracture of the sternum, ribs, or both
- •Has lung cancer within the last 2 years
- •chronic bronchitis with an increase in severity within the last 30 days
- •tuberculosis on treatment
- •suspected atypical pneumonia
Outcomes
Primary Outcomes
Not specified
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