Impact of Environmental Factors and Metabolomics on Colorectal Cancer Development and Prognosis Based on Environmental Factors and Metabolomics.
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Rate of postoperative complications
研究概览
简要总结
Colorectal cancer is one of the malignant tumours with high morbidity and mortality worldwide, posing a serious threat to human health. In recent years, the incidence of colorectal cancer has been on the rise with changes in lifestyle and dietary habits. Although some progress has been made in treatments such as surgery, chemotherapy and radiotherapy, however, the early diagnosis, prognosis assessment and personalised treatment of colorectal cancer still face great challenges. Therefore, it is of great academic value and practical significance to deeply explore the influencing factors of colorectal cancer occurrence, development and its prognosis, especially the research on environmental factors and metabolomics.
详细描述
In this study, investigators collected clinical information, blood, urine and stool for ambient air pollution analysis, blood metabolomics analysis and stool macro-genetic sequencing by including patients from healthy control and colorectal cancer groups, respectively. Environmental factors, metabolomics and intestinal microbiota data were integrated and analysed to screen for indicators that play a key role in colorectal cancer development and construct a colorectal cancer prediction model.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy control group:
- •age ≥18 years old;
- •no history of malignant tumour;
- •willing to participate in this study and sign the informed consent form;
- •complete basic data.
- •Gastric cancer group:
- •age ≥18 years old;
- •patients diagnosed with gastric cancer by pathological biopsy before operation;
- •no chemotherapy, radiotherapy, targeted and immunotherapy before enrolment;
- •willing to participate in this study and sign the informed consent; complete clinical data.
- •Exclusion criteria:
- •patients with primary malignant tumours other than gastric cancer;
- •patients with serious cardiopulmonary insufficiency and other systemic diseases that affect the choice of treatment plan;
- •patients who are not suitable for enrolment as assessed by the investigator.
排除标准
- 未提供
结局指标
主要结局
Rate of postoperative complications
时间窗: From date of surgery until the date of first documented postoperative complication, assessed up to 2 months after surgery.
Surgical complications was defined as any postoperative complication occurring during the postoperative hospitalisation period.
次要结局
- Overall survival(From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months.)
研究者
Dong Peng
Principal Investigator
First Affiliated Hospital of Chongqing Medical University