NCT04626193Unknown4 期
Comparing the Efficacy of Two Weeks Therapy of Doxycycline,Levofloxacin,Tinidazole Versus Levofloxacin With Tinidazole on Rate of Eradication of Helicobacter Pylori Infected Patients on Syrian Population
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Eradication rate of Helicobacter pylori infection
研究概览
简要总结
Comparison Efficacy of two weeks Therapy with Doxycycline,levofloxacine,Tinadizole Versus Levofloxacine,Tinadizole,Amocillin on Eradication of Helicobacter Pylori in Syrian population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients are aged greater than 18 years old who have H. pylori infection diagnosed by any of following three methods:
- •Positive rapid urease test (CLOtest).
- •Histologic evidence of H. pylori by modified Giemsa staining.
- •Positive 13C-urea breath test. without prior eradication therapy and are willing to receive therapy.
排除标准
- •Children and teenagers aged less than 18 years.
- •Previous eradication treatment for H. pylori.
- •Patients who took any drug, which could influence the study results such as proton pump inhibitor, H2 blocker, mucosal protective agent and antibiotics.
- •History of gastrectomy.
- •Gastric malignancy, including adenocarcinoma and lymphoma,
- •Previous allergic reaction to antibiotics (Amoxicillin, Tinadizole,
- •Doxycycline,Bismuth subsalicylate,) and prompt pump inhibitors (Es- omeprazole).
- •Contraindication to treatment drugs.
- •Pregnant or lactating women.
- •Severe concurrent disease.
- •Liver cirrhosis.
研究组 & 干预措施
Doxycyclien
Experimental
Measure eradication rate of Helicobacter pylori infection with Doxycycline,Levofloxacien,tinadizole
干预措施: Doxycycline (Drug)
Levofloxacine
Active Comparator
Measure eradication rate of Helicobacter pylori infection with Livofloxacine and tinadizole,amoxicilline
干预措施: Levofloxacin 500mg (Drug)
结局指标
主要结局
Eradication rate of Helicobacter pylori infection
时间窗: 8 week from begning of treatment
Eradication rate of Helicobacter infected patients
次要结局
未报告次要终点
研究者
Marouf Alhalabi
head of digestive diseases department
Damascus Hospital
研究点 (1)
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