LOAD VS Levofloxacine Concomitant
Phase 4
- Conditions
- Helicobacter Pylori Infection
- Interventions
- Registration Number
- NCT04626193
- Lead Sponsor
- Damascus Hospital
- Brief Summary
Comparison Efficacy of two weeks Therapy with Doxycycline,levofloxacine,Tinadizole Versus Levofloxacine,Tinadizole,Amocillin on Eradication of Helicobacter Pylori in Syrian population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- Patients are aged greater than 18 years old who have H. pylori infection diagnosed by any of following three methods:
- Positive rapid urease test (CLOtest).
- Histologic evidence of H. pylori by modified Giemsa staining.
- Positive 13C-urea breath test. without prior eradication therapy and are willing to receive therapy.
Exclusion Criteria
- Children and teenagers aged less than 18 years.
- Previous eradication treatment for H. pylori.
- Patients who took any drug, which could influence the study results such as proton pump inhibitor, H2 blocker, mucosal protective agent and antibiotics.
- History of gastrectomy.
- Gastric malignancy, including adenocarcinoma and lymphoma,
- Previous allergic reaction to antibiotics (Amoxicillin, Tinadizole,
- Doxycycline,Bismuth subsalicylate,) and prompt pump inhibitors (Es- omeprazole).
- Contraindication to treatment drugs.
- Pregnant or lactating women.
- Severe concurrent disease.
- Liver cirrhosis.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Levofloxacine Levofloxacin 500mg Measure eradication rate of Helicobacter pylori infection with Livofloxacine and tinadizole,amoxicilline Doxycyclien Doxycycline Measure eradication rate of Helicobacter pylori infection with Doxycycline,Levofloxacien,tinadizole
- Primary Outcome Measures
Name Time Method Eradication rate of Helicobacter pylori infection 8 week from begning of treatment Eradication rate of Helicobacter infected patients
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie doxycycline's efficacy against Helicobacter pylori in combination therapies?
How does the eradication rate of doxycycline-levofloxacin-tinidazole compare to standard triple therapy in Syrian populations?
Which biomarkers correlate with Helicobacter pylori eradication success in antibiotic combination regimens?
What adverse event profiles differentiate levofloxacin-based therapies from doxycycline-containing regimens in H. pylori treatment?
How do fluoroquinolone and tetracycline antibiotics synergize with tinidazole in H. pylori eradication protocols?
Trial Locations
- Locations (1)
General Assembly of Damascus Hospital
🇸🇾Damascus, Syrian Arab Republic
General Assembly of Damascus Hospital🇸🇾Damascus, Syrian Arab RepublicMarouf MI Alhalabi, MDContact+963952781278e.marouf@hotmail.com