One hundred percent oxygen versus titrated oxygen following the return of a heartbeat after out of hospital cardiac arrest: a feasibility study

Completed

• Conditions: Specialty: Injuries and emergencies, Primary sub-specialty: Injuries and emergencies; Circulatory System; Out of hospital cardiac arrest (OHCA)

• Registration Number: ISRCTN49548506
• Lead Sponsor: niversity Hospitals Bristol NHS Foundation Trust

Brief Summary

2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/30683057

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2015-10-31
• Study Start: 2016-11-24
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

1. Sustained a cardiac arrest in the pre-hospital setting believed to be of a non-traumatic cause. Cardiac arrest will be defined according to the Utstein Definition as the cessation of cardiac mechanical activity as confirmed by the absence of signs of circulation. If an EMS provider or physician did not witness the cardiac arrest, he/she may be uncertain as to whether a cardiac arrest actually occurred. For the purposes of this study, patients will be eligible for inclusion if they are attended by ambulance staff and are believed by those staff to have suffered a cardiac arrest.
2. ROSC (indicated by signs of circulation: usually a palpable central or peripheral pulse) for greater than 2 minutes (sustained ROSC) has been achieved
3. Attended by a paramedic participating in the trial
4. Known, or believed to be, 18 years of age, or older

Exclusion Criteria

1. Less than 18 years old
2. Cardiac arrest believed to have been caused by trauma (including hanging and drowning)
3. Entered into the study previously
4. Detained by Her Majesty's Prison Service

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recruitment rate is measured as the proportion of eligible paramedics attending training and consenting to take part at the end of the recruitment period.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Proportion of surviving participants providing quality of life data at discharge and 90 days is measured by the number of patients completing the modified Rankin Scale, EuroQol EQ-5D-5L and the SF-36 instruments at discharge and 90 days following OHCA<br> 2. Survival to discharge and 90-days is measured by reviewing patient notes at hospital discharge and 90 days following OHCA<br>