Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity

• Conditions: Preeclampsia; Placental Abruption; Intrauterine Fetal Growth Restriction; Pregnancy Complications; Intrauterine Fetal Death

• Registration Number: NCT00573118
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

Congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction (IUGR), placental abruption, intrauterine fetal death (IUFD) and repeated pregnancy loss.These severe pregnancy complications are thought to result from thrombotic events occurring in the uteroplacental circulation. Accumulating data have established an association between elevated plasma activity of factor VIII and thrombosis although the mechanism is still not defined and elevated factor VIII activity is now regarded as being equivalent to thrombophilia.

We intend to investigatthe association between factor VIII levels and severe pregnancy complications which are considered to result from placental vascular pathology, i.e., preeclampsia, IUGR, placental abruption and IUFD. We hypothezise that the prevalence of elevated factor 8 will be higher among women with pregnancy complications compared to controls.

Detailed Description

Not available

Study Timeline

• Study Start: 2000-01
• Status Verified: 2007-12
• Study First Submitted: 2007-12-12
• Study First Submitted QC: 2007-12-12
• Last Update Submitted: 2007-12-12
• Study First Posted: 2007-12-13
• Last Update Posted: 2007-12-13
• Study Completion: 2008-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• Women who had either normal pregnancy or complicated pregnancy.

Exclusion Criteria

• Other causes of pregnancy complication such as infections, anomalies and fetal malformations

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevalenc of elevated factor VIII	RETROSPECTIVE

Trial Locations

Locations (1)

Tel Avis sourasky medical center; 🇮🇱 Tel Aviv, Israel