Randomized Phase II Trial Evaluating Modified FOLFIRINOX and Modified FOLFOX in the Treatment of Locally Advanced or Metastatic Small Bowel Adenocarcinoma

Centre Hospitalier Universitaire Dijon1 site in 1 country130 target enrollmentFebruary 16, 2024

ConditionsLocally Advanced or Metastatic Small Bowel Adenocarcinoma

Interventionsmodified FOLFORINOX Modified FOLFOX

DrugsModified FOLFOX modified FOLFORINOX

Overview

Phase: Phase 2
Intervention: modified FOLFORINOX
Conditions: Locally Advanced or Metastatic Small Bowel Adenocarcinoma
Sponsor: Centre Hospitalier Universitaire Dijon
Enrollment: 130
Locations: 1
Primary Endpoint: Assess the percentage of patients alive without progression
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

Randomized, non-comparative, open-label, multi-centre Phase II study to evaluate modified FOLFIRINOX and modified FOLFOX in the locally advenced or metastatic small bowel adenocarcinoma.

The primary objective is to assess the percentage of patients alive without prograssion at 8 months.

Registry

clinicaltrials.gov

Start Date

February 16, 2024

End Date

February 2029

Last Updated

2 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Centre Hospitalier Universitaire Dijon

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Histologically proven adenocarcinoma of the small intestine (duodenum, jejunum, ileum)
•Metastatic or locally advanced unresectable tumour with curative intent
•Patient who never received first-line chemotherapy
•Measurable lesion according to RECIST 1.1 criteria
•ECOG status \< or = 2 for patients under 70 years, or 0 or 1 for patients over 70 years
•Life expectancy estimated at over 3 months
•Patient over 18 years of age
•Patient able to understand and sign the information and informed consent note
•Women of childbearing age and men who have sex with women of childbearing age must agree to use contraception during the trial treatment and for at least 9 months after stopping the experimental treatments.

Exclusion Criteria

•MSI/dMMR tumor
•Adenocarcinoma of the ampulla of Vater
•Neutrophils \< 1500/mm3, platelets \< 100 000/mm3
•Hemoglobin \< 9 g/dL, total bilirubin \> 1.5x normal, alkaline phosphatase \> 2.5x normal (or \>5x normal if liver metastases), creatinine clearance \> or = 40 ml/min. according to MDRD
•Hypokalaemia, hypomagnesaemia and hypocalcaemia below normal, and for calcaemia, it must be corrected before enrolment.
•Adjuvant chemotherapy completed less than 6 months ago
•History of myocardial infarction within the last 6 months, severe coronary artery disease or severe heart failure
•Severe renal failure
•Peripheral sensory neuropathy with functional discomfort
•Active and/or potentially severe infection or other uncontrolled conditions