A Randomized, Controlled Crossover Trial to Assess the Effects of Varying Meals on Satiety
试验速览
- 阶段
- 不适用
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Composite Area under the Curve - Visual Analog Scale
研究概览
简要总结
The primary objective of this study is to assess the acute effects of different meals on satiety. It is hypothesized that a lower carbohydrate meal will result in greater feelings of satiety and reduced food intake at a subsequent meal compared to the higher-carbohydrate or meal skipping conditions.
详细描述
Satiety refers to feelings of fullness or lack of desire to eat following consumption of a food or meal. A number of dietary factors have been shown to influence satiety, including food volume, food weight, energy density, food palatability, and certain food ingredients. The nutritional composition of a meal appears to also play a significant role in an individual's feelings of satiety and ability to stay full until the next meal.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •premenopausal Females
- •Ages 18-55
- •BMI between 18.5-29.9
- •Willing to maintain weight throughout study period
排除标准
- •Subject has a history of any surgical intervention for the treatment of obesity
- •Recent history or use of weight loss drugs, herbal supplements or on a dieting program or trying to loose weight
- •Gains or loses more than 6 pounds over the study period
- •Current or history of an eating disorder
- •Restrained eater
- •Excludes any foods or meals from their diet
- •History or presence of clinically important cardiac, renal, hepatic, endocrine, pulmonary, gastrointestinal, biliary, pancreatic or neurologic disorders
- •Signs of an infection
- •Heavy user of caffeine or alcohol
- •Unconventional sleep patterns (e.g. works 3rd shift)
- •Subject is pregnant or planning to become pregnant during the study period
结局指标
主要结局
Composite Area under the Curve - Visual Analog Scale
时间窗: Acute - up to 4 hrs
次要结局
- Individual satiety measures - Area under the curve(4 hrs)