To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy

Not Applicable

Completed

• Conditions: Induced Abortion; Postaboral Pelvic Inflammatory Disease; Sexually Transmitted Infections
• Interventions: Drug: Universal antibiotic prophylaxis; Other: Screen-and-treat

• Registration Number: NCT01842100
• Lead Sponsor: The University of Hong Kong

Brief Summary

Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when compared to the universal antibiotic prophylaxis strategy.

Detailed Description

While universal antibiotic prophylaxis during induced abortion has been proven to reduce postabortal pelvic inflammatory diseases, screen-and-treat approach has the potential benefit of altering women's sexual behavior and preventing further re-infection by sexually transmitted infections. We conducted a randomized controlled trial to compare the effect of the two approaches in preventing postabortal pelvic inflammatory disease and the women's sexual behavior.

Study Timeline

• Study Start: 1999-09
• Primary Completion: 2006-02
• Study Completion: 2006-02
• Status Verified: 2013-04
• Study First Submitted: 2013-04-21
• Study First Submitted QC: 2013-04-24
• Last Update Submitted: 2013-04-24
• Study First Posted: 2013-04-29
• Last Update Posted: 2013-04-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 2193

Inclusion Criteria

• women requesting for induced abortion in the gynecology clinic

Exclusion Criteria

• nil

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Universal antibiotic prophylaxis	Universal antibiotic prophylaxis	In the universal prophylaxis group, all women received doxycycline 100 mg twice daily for 7 days starting on the day of induced abortion. Screening for sexually transmitted diseases was done as baseline but the results were not revealed to the patients.
Screen-and-treat	Screen-and-treat	In the screen-and-treat group, the results of screening for sexually transmitted infections (STI) were revealed to the patients. They would only receive appropriate specific antibiotics treatment only if they were screened positive for any of the STIs. If they were found to have STI, their sexual partners would also be referred to the local social hygiene clinics for contact tracing and treatment. Contraception by barrier methods would also be advised.

Primary Outcome Measures

Name	Time	Method
Rate of postabortal inflammatory disease 6 weeks after induced abortion.	6 weeks after induced abortion.

Secondary Outcome Measures

Name	Time	Method
Rate of re-infection by sexually transmitted infections 24 weeks after induced abortion.	24 weeks after induced abortion.
Proportion of women having abstinence from sexual intercourse or using condom at 6 weeks, 24 weeks and 1 year after induced abortion.	6 weeks, 24 weeks and 1 year after induced abortion

Trial Locations

Locations (1)

Queen Mary Hospital; 🇨🇳 Hong Kong, Hong Kong, China