Immune response to pre-exposure rabies vaccination via intradermal route compared to intramuscular in kidney transplant recipients

Phase 3

Recruiting

• Conditions: Rabies neutralizing antibody; Rabies vaccination; Kidney transplant recipient; Immune response

• Registration Number: TCTR20200716006
• Lead Sponsor: Ratchadapisek Sompoch Endowment Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-06-30
• Study Start: 2020-07-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Patients aged above 18 years who underwent kidney transplantation more than 3 months prior with functioning renal allograft at the time of randomization.

Exclusion Criteria

Patients who had previous rabies vaccination, intravenous immunoglobulin within 3 months, acute febrile illness within 1 week, detectable cytomegalovirus (CMV) viremia, CMV disease or contraindications for ID or IM injections were excluded

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Seroconversion rate of participants Day 42 after the first vaccination Rabies neutralizing antibody >0.5 IU/ml

Secondary Outcome Measures

Name	Time	Method
Geometric mean titers Day 42 after 1st vaccination RVNA