Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities

• Conditions: Periodontitis; Vascular Disease

• Registration Number: NCT01358630
• Lead Sponsor: University of Oslo

Brief Summary

The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Status Verified: 2010-11
• Primary Completion: 2011-03
• Study First Submitted: 2011-05-19
• Study First Submitted QC: 2011-05-23
• Last Update Submitted: 2011-05-23
• Study First Posted: 2011-05-24
• Last Update Posted: 2011-05-24
• Study Completion: 2015-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,

Exclusion Criteria

• patients whom undergone antibiotic treatment the past month.
• patients whom undergone periodontal treatment the past 6 months.
• patients with no teeth

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Dental and Medical Faculty, University of Oslo; 🇳🇴 Oslo, Norway