NCT05628610尚未招募2 期
Tislelizumab Combined With Chemotherapy or Radiotherapy in the Treatment of Advanced or Recurrent Metastatic Elderly Esophageal Cancer
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 130
- 主要终点
- objective response rate
研究概览
简要总结
To compare the objective response rate (ORR) and safety of tislelizumab combined with chemotherapy and Tislelizumab combined with radiotherapy in elderly patients with esophageal cancer with advanced or recurrent metastasis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed a written informed consent and volunteered to join the study;
- •Patients with esophageal squamous cell carcinoma confirmed by pathological histological and / or immunohistochemical examination or progressing after surgical resection, (the 8th edition, 2017) with UICC / AJCC TNM stage cT4N0-2M0, c any TN3M0, or c any T any NM1 (clinical stage IV);
- •Unresectable advanced, recurrent, or metastatic oesophageal SCC;
- •Age: 70 years old;
- •E CO G P S 0-2
- •Has not received any systemic antitumor treatment for esophageal cancer, including radiotherapy, chemotherapy, targeted, immunotherapy, etc.;
- •At least one measurable lesion was present
- •Main organs have normal function, including:
- •A) Routine blood tests (no blood components, cell growth factors, whitening agents, platelets, anemia drugs are allowed within 14 days before the first use of the study drug) Leukocyte count was at 3.0109/L Neutrophil count was at 1.0109/L Platelet count was at 8,0109/L Hemoglobin was at 80 g / L b) Blood biochemical examination: Total bilirubin was at 1.5 ULN ALT ≤ 2.5×ULN ，AST ≤2.5×ULN ， Serum creatinine of 1.5 ULN, or creatinine clearance of 45 mL/min (Cocheroft-Gault formula, see Annex 2)
- •The subjects had good compliance and cooperated with the follow-up
排除标准
- •There is uncontrollable pleural effusion, pericardial effusion or ascites that requires repeated drainage;
- •Poor nutritional status, BMI <18.5 Kg / m2; if corrected after symptomatic nutritional support, further enrollment can be considered after evaluation by the principal investigator;
- •Gastrointestinal bleeding (bleeding volume> 200ml / day);
- •Patients adjudged by the researchers to have deep ulcers;
- •Previous history of allergy to monoclonal antibodies, any component of tirellizumab, paclitaxel, cisplatin, or other platinum drugs;
- •Has received or are receiving any of the following treatments:
- •A) Any radiotherapy, chemotherapy, or other antitumor drugs directed against the tumor; Study drug b) Treatment with immunosuppressive drugs or systemic hormones for immunosuppression purposes within 2 weeks of the first study drug (dose or equivalent dose> 10mg / day); inhaled or topical steroids and doses> 10mg / day prednisone or equivalent dose of adrenal corticoid replacement in the absence of active autoimmune disease; The c) Acceptance of a live attenuated vaccine within 4 weeks before the first use of the study drug; d) Major surgery or severe trauma within 4 weeks prior to the first use of the study drug;
- •History of any active autoimmune or autoimmune disease, including but not limited to: interstitial pneumonia, enteritis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism (considered after HRT); patients with psoriasis or asthma / allergy in childhood remission and adults without any intervention, but patients requiring bronchodilator are not included;
- •A history of immunodeficiency, including positive HIV testing, or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation or allogeneic bone marrow transplantation;
- •Poor clinical cardiac symptoms or disease, including but not limited to:
- •Such as (1) heart failure of grade NYHAII or above; (2) unstable angina pectoris; (3) myocardial infarction within 1 year; (4) clinical significance of supraventricular or ventricular arrhythmia without clinical intervention or clinical intervention is not well controlled;
- •Severe infection (CTCAE> 2) within 4 weeks before initial use of study drug, such as severe pneumonia, bacteremia, or infection complications requiring hospitalization; baseline chest imaging indicates active lung inflammation, symptoms or signs of infection within 14 days prior to initial use of study drug, or requiring oral or intravenous antibiotics, except for prophylactic antibiotics;
- •Patients with active tuberculosis infection by medical history or CT examination, or active tuberculosis infection within 1 year prior to enrollment, or active tuberculosis infection within 1 year before enrollment, or before enrollment but without formal treatment;
- •The presence of active hepatitis B (HBV DNA 2000 IU / mL or 104 copies / mL), hepatitis C (hepatitis C antibody positive, and HCV RNA above the lower limit of the analysis method);
- •According to the investigator, there are other factors present that may lead to the forced termination of the study, such as other serious illness (including mental illness) requiring combined treatment, alcohol abuse, substance abuse, family or social factors, that may affect the safety or compliance of the subject.
研究组 & 干预措施
Tislelizumab combined with radiotherapy
Experimental
干预措施: Tislelizumab (Drug)
Tislelizumab combined with radiotherapy
Experimental
干预措施: Radiation (Radiation)
Tislelizumab combined with chemotherapy
Experimental
干预措施: Tislelizumab (Drug)
Tislelizumab combined with chemotherapy
Experimental
干预措施: Paclitaxel (Drug)
结局指标
主要结局
objective response rate
时间窗: 12 months
Clinical response of treatment according to RESIST v1.1 criteria (ORR, objective response rate).
次要结局
- progression free survival(12 months)
研究者
相似试验
招募中
2 期
Tislelizumab Combined With Concurrent Chemoradiotherapy as First-line Treatment for Stage IIIC2 Cervical CancerCervical CancerNCT05511623First Affiliated Hospital of Guangxi Medical University112
招募中
2 期
Tislelizumab Combined With Concurrent Chemoradiotherapy for Locally Advanced Cervical CancerUterine Cervical NeoplasmsNCT05588219Yong Zhang,MD30
Unknown
2 期
Study of Tislelizumab Plus Chemotherapy vs Chemotherapy as Perioperative Treatment in Participants With HER2 Negative Breast CancerHER2-negative Breast CancerNCT04498793Cancer Institute and Hospital, Chinese Academy of Medical Sciences55
招募中
2 期
Tislelizumab Combined With Chemotherapy Followed by Surgery Versus Up-front Surgery in Resectable Clinically Node-negative Head and Neck Squamous Cell CarcinomaHead and Neck Squamous Cell CarcinomaNCT06323369Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University154
进行中（未招募）
2 期
Tislelizumab, Gemcitabine and Cisplatin for R/R Hodgkin Lymphoma Followed by Tislelizumab Consolidation in Patients in Metabolic Complete RemissionHodgkin LymphomaNCT05502250Stichting Hemato-Oncologie voor Volwassenen Nederland75