Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures

Phase 3

Recruiting

• Conditions: Partial Epilepsy
• Interventions: Drug: Xcopri

• Registration Number: NCT05067634
• Lead Sponsor: SK Life Science, Inc.

Brief Summary

Primary objective: To evaluate the safety and tolerability of cenobamate in pediatric subjects 2-17 years of age with partial-onset (focal) seizures

Detailed Description

Secondary objectives:

* To evaluate the efficacy of cenobamate tablets and suspension in pediatric subjects with partial onset (focal) seizures

* To evaluate the pharmacokinetics of cenobamate tablets and suspension in pediatric subjects with partial onset seizures

* To evaluate the PK/pharmacodynamics of cenobamate in pediatric subjects with partial onset (focal) seizures

* Acceptability and palatability assessment (determined by a 5-point Hedonic Scale) of the oral formulation and the 12.5 mg tablets - Day 1, and Day 15

Study Timeline

• Study First Submitted: 2021-09-14
• Study First Submitted QC: 2021-09-23
• Study First Posted: 2021-10-05
• Study Start: 2022-01-14
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-20
• Last Update Posted: 2025-03-24
• Primary Completion: 2026-05
• Study Completion: 2026-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

1. Have a diagnosis of epilepsy with partial-onset (focal) seizures (POS) with or without secondarily generalized seizures according to the International League Against Epilepsy's (ILAE) Classification of Epileptic Seizures. A diagnosis should have been established at least 12 months prior to Visit 1 (Screening) by clinical history and an electroencephalogram (EEG) that is consistent with the diagnosis; normal interictal EEGs will be allowed provided that the participant meets the other diagnosis criterion (i.e., clinical history)

2. Male or female participant, from age 2 to less than 18 years at the time of informed consent/assent (dates including informed consent in YKP3089C039)

3. Have a minimum weight of 10.0 kilograms (kg) (22.0 pounds [lb])

4. Have had a brain imaging (e.g., magnetic resonance imaging [MRI] scan or computed tomography (CT) within 10 years before Visit 1 (Screening) that ruled out a progressive cause of epilepsy.

5. For subjects new to Study YKP3089C040, participants must have had at least 1 POS seizure during the 28-day Baseline Period. Only simple POS with motor signs, complex POS, and complex POS with secondary generalization are counted toward this inclusion for POS

6. Are currently being treated with stable doses of 1 to a maximum of 3 approved antiepileptic drugs (AEDs). Doses must be stable for at least 4 weeks before to Visit 1 (Screening). A vagal nerve stimulator [VNS] will not be counted as one of the 3 allowed AEDs but the settings should be stable for at least 4 weeks prior to Visit 1 (Screening).

7. Investigator believes subject could benefit from new or continued exposure to study drug

8. Subjects entering from study YKP3089C039 must continue to meet all of the inclusion criteria from the YKP3089C039 study

9. Subjects receiving felbamate as a concomitant AED must meet the following criteria:

   1. Have a 12-month history of felbamate use and a history of a fixed dosing regimen for a minimum of 60 days prior to Visit 1 (Screening).
   2. No prior or known history of hepatotoxicity or hematologic disorder due to felbamate.

10. Subjects following a ketogenic diet will be allowed as long as the diet has been stable for at least 30 days prior to Visit 1 (Screening) and will remain stable for the duration of the study

Exclusion Criteria

1. Females who are breastfeeding or pregnant at Screening or Baseline.
2. Current or history of pseudo-seizures (psychogenic nonepileptic seizures) within approximately 2 years before Visit 1 (Screening).
3. Have a history of status epilepticus that required hospitalization during the 6 months before Visit 1 (Screening).
4. Have an unstable psychiatric diagnosis that may confound participants' ability to participate in the study or that may prevent completion of the protocol-specified tests (e.g., significant suicide risk, including suicidal behavior and ideation within 6 months before Visit 1 (Screening), current psychotic disorder, acute mania).
5. Any suicidal ideation with intent, with or without a plan within 6 months before Visit 2 [i.e., answering "Yes" to questions 4 or 5 on the Suicidal Ideation section of the Columbia-Suicide Severity Rating Scale (C-SSRS) in participants aged 6 and above, if able].
6. Are scheduled and/or confirmed to have epilepsy surgery within 6 months after Visit 1 (Screening); however, those who have previously documented "failed" epilepsy surgery will be allowed.
7. Evidence of clinically significant disease (e.g., cardiac, respiratory, gastrointestinal, renal disease) that in the opinion of the investigator(s) could affect the participant's safety or interfere with the study assessments.
8. Presence of only nonmotor simple partial seizures or primary generalized epilepsies.
9. Evidence of moderate or severe renal insufficiency as defined by estimated glomerular filtration rates (eGFRs) of 31 to < 60 "milliliters per minute (mL/min)" and < 30 mL/min, respectively.
10. Evidence of significant active hepatic disease. Stable elevation of liver enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) due to concomitant medication(s), will be allowed if they are less than 3 times the upper limit of normal (ULN).
11. Evidence of significant active hematological disease; white blood cell (WBC) count equal or less than 2500/µL (2.50 1E+09/liter [L]) or an absolute neutrophil count equal or less than 1000/µL (1.00 1E+09/L).
12. Subjects with Familial short QT syndrome.
13. Clinically significant electrocardiogram (ECG) abnormality, including prolonged corrected QT interval (QTc) defined as greater than 450 milliseconds (msec) or shortened corrected QT interval (QTc) defined as less than 340 msec.
14. Have a progressive central nervous system (CNS) disease, including degenerative CNS diseases and progressive tumors.
15. Subject has a history of any serious drug-induced hypersensitivity reaction (including, but not limited to, Stevens Johnson syndrome, toxic epidermal necrolysis, or DRESS) or any drug-related rash requiring hospitalization.
16. History of AED-associated rash that involved conjunctiva or mucosae.
17. History of more than one non-serious drug-related hypersensitivity reaction that required discontinuation of the medication.
18. Concomitant use of vigabatrin. Participants who took vigabatrin in the past must be off vigabatrin for at least 5 months before Visit 1 (Screening) and with documentation showing no evidence of a vigabatrin-associated clinically significant abnormality in a visual perimetry test.
19. A history of intermittent use of rescue benzodiazepines (i.e., 1 to 2 doses over a 24-hour period is considered a 1-time rescue) more than once within the 30 days prior to Visit 1(Screening).
20. A VNS implanted less than 5 months before Visit 1 (Screening) or changes in parameter less than 4 weeks before Visit 1 (or thereafter during the study).
21. History of or a concomitant medical condition that in the opinion of the investigator(s) would preclude the participant's participation in a clinical study or compromise the participant's ability to safely complete the study.
22. Have participated in a study involving administration of an investigational drug or device within 4 weeks before Visit 1 (Screening), or within approximately 5 half-lives of the previous investigational compound, whichever is longer.
23. Participants with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
24. For subjects new to Study YKP3089C040 previous exposure to cenobamate or sensitivity/allergy to components of the oral suspension.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
12 to < 18 year olds	Xcopri	-
6 to <12 years old	Xcopri	-
4 to <6 years old	Xcopri	-
2 to <4 years old	Xcopri	-

Primary Outcome Measures

Name	Time	Method
Incidence of Adverse Events and SAEs	3 Years	Summary statistics for clinical laboratory test results and vital signs; and physical examination, neurologic examination and electrocardiogram (ECG) finding.of age with partial-onset (focal) seizures

Secondary Outcome Measures

Name	Time	Method
To collect plasma samples of cenobamate to support the evaluation of the pharmacokinetics of cenobamate tablets and suspension in pediatric subjects with partial onset (focal) seizures	3 Years	The area under the curve (AUC) of Xcopri after a single and multiple doses of Xcopri
Acceptability and palatability assessment (determined by a 5-point Hedonic Scale) of the oral formulation and tablets	3 Years	Testing to determine how patients respond to the taste and route of Xcopri

Trial Locations

Locations (55)

Diakonie Kork; 🇩🇪 Kehl, Germany

Phoenix Children's Hospital; 🇺🇸 Phoenix, Arizona, United States

Lucile Packard Children's Hospital Stanford; 🇺🇸 Palo Alto, California, United States

University of California Davis Health; 🇺🇸 Sacramento, California, United States

Connecticut Children's Medical Center; 🇺🇸 Hartford, Connecticut, United States

Augusta University Medical Center; 🇺🇸 Augusta, Georgia, United States

Clinical Integrative Research Center of Atlanta; 🇺🇸 Sandy Springs, Georgia, United States

Meridian Clinical Research - Savannah Neurology Specialists; 🇺🇸 Savannah, Georgia, United States

Kentucky Clinic; 🇺🇸 Lexington, Kentucky, United States

Mid-Atlantic Epilepsy and Sleep Center; 🇺🇸 Bethesda, Maryland, United States

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States

Spectrum Health Hospitals Helen DeVos Children's Hospital; 🇺🇸 Grand Rapids, Michigan, United States

Mayo Clinic - Rochester; 🇺🇸 Rochester, Minnesota, United States

University of Missouri Health Care - Women's and Children's Hospital; 🇺🇸 Columbia, Missouri, United States

Northeast Regional Epilepsy Group; 🇺🇸 Hackensack, New Jersey, United States

Northeast Regional Epilepsy Group - Morristown; 🇺🇸 Morristown, New Jersey, United States

Boston Children's Health Physicians - Neurology at Hawthorne; 🇺🇸 Hawthorne, New York, United States

Duke University Hospital; 🇺🇸 Durham, North Carolina, United States

Akron Children's Hospital NeuroDevelopmental Science Center/Pediatric Neurology; 🇺🇸 Akron, Ohio, United States

Cincinnati Children's Hospital; 🇺🇸 Cincinnati, Ohio, United States

Cleveland Clinic Main Campus; 🇺🇸 Cleveland, Ohio, United States

Children's Hospital of Philadelphia; 🇺🇸 Philadelphia, Pennsylvania, United States

Le Bonheur Children's Hospital; 🇺🇸 Memphis, Tennessee, United States

Child Neurology Consultants of Austin; 🇺🇸 Austin, Texas, United States

Scottish Rite for Children; 🇺🇸 Dallas, Texas, United States

MultiCare Institute - Mary Bridge Children's Neurology; 🇺🇸 Tacoma, Washington, United States

Austin Health; 🇦🇺 Heidelberg, Australia

Royal Children's Hospital Melbourne; 🇦🇺 Parkville, Australia

Sydney Children's Hospital - Randwick; 🇦🇺 Randwick, Australia

Children's Health Queensland Hospital and Health Service; 🇦🇺 South Brisbane, Australia

Charite University Hospital; 🇩🇪 Berlin, Germany

Universitätsklinikum Schleswig-Holstein - Campus Kiel; 🇩🇪 Kiel, Germany

Neurologische Klinik und Poliklinik Interdisziplinäres Epilepsiezentrum München; 🇩🇪 Munich, Germany

Universitätsklinikum Tübingen; 🇩🇪 Tübingen, Germany

Bethesda Gyermekkorhaz; 🇭🇺 Budapest, Hungary

Országos Klinikai Idegtudományi Intézet, Neurológiai Osztály; 🇭🇺 Budapest, Hungary

Semmelweis University Dept. Of Paediatrics; 🇭🇺 Budapest, Hungary

Servus Salvus Egészségügyi Szolgáltató Kft.; 🇭🇺 Budapest, Hungary

Debreceni Egyetem Klinikai Központ; 🇭🇺 Debrecen, Hungary

Chungbuk National University Hospital; 🇰🇷 Cheonju, Korea, Republic of

Korea University Guro Hospital; 🇰🇷 Seoul, Korea, Republic of

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of

Severance Hospital; 🇰🇷 Seoul, Korea, Republic of

SMG-SNU Boramae Medical Center; 🇰🇷 Seoul, Korea, Republic of

Ajou University Hospital; 🇰🇷 Suwon, Korea, Republic of

Niepubliczny Zaklad Opieki Zdrowotnej - Centrum Neurologii Dzieciecej i Leczenia Padaczki; 🇵🇱 Kielce, Poland

Centrum Medyczne Plejady; 🇵🇱 Kraków, Poland

Wojewódzki Specjalistyczny Szpital Dziecięcy im. św. Ludwika w Krakowie; 🇵🇱 Kraków, Poland

Hospital Sant Joan de Déu Barcelona; 🇪🇸 Barcelona, Spain

Hospital Universitari Vall d'Hebrón; 🇪🇸 Barcelona, Spain

Hospital Infantil Universitario Niño Jesús; 🇪🇸 Madrid, Spain

Hospital Universitario La Paz; 🇪🇸 Madrid, Spain

Clinica Universidad de Navarra - Pamplona; 🇪🇸 Pamplona, Spain

Instituto de Investigación Sanitaria de la Fundación Ramón Domínguez; 🇪🇸 Santiago De Compostela, Spain

Hospital Universitario Virgen del Rocío; 🇪🇸 Sevilla, Spain