Cortical-Basal Ganglia Speech Networks
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- The number of subjects providing the interpretable speech related electrophysiological data collection.
研究概览
简要总结
In this research study the researchers want to learn more about brain activity related to speech perception and production.
详细描述
Speech production is disrupted in a number of neurological diseases that involve the basal ganglia, including Parkinson's disease (PD) and dystonia. The investigators will use a novel experimental approach and combination of analytic techniques to elucidate the contribution of neural activity in cortical-basal ganglia circuits to the hierarchical control of speech production, in subjects undergoing deep brain stimulation surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects scheduled for DBS implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of Parkinson's disease, essential tremor or dystonia.
- •Subjects able to provide informed consent and comply with task instructions.
- •Subjects 18-85 years old
排除标准
- •Subjects with reported hearing loss.
- •Non-English-speaking subjects
结局指标
主要结局
The number of subjects providing the interpretable speech related electrophysiological data collection.
时间窗: Duration of single DBS surgery
The number of subjects providing the interpretable speech related electrophysiological data during DBS surgery.
次要结局
未报告次要终点
研究者
Robert Mark Richardson
Director of Functional Neurosurgery
Massachusetts General Hospital