The elucidation of placental origins of pregnancy disorders.

Not Applicable

Recruiting

• Conditions: Fetal growth restriction and hypertensive pregnancy disorders

• Registration Number: JPRN-UMIN000028772
• Lead Sponsor: Mie university hospital, Department of Obstetrics and Gynecology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-08-22
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

1. Age>=20
2. Gestational age between 20 + 0 and 33 + 6 weeks in pregnant women.
3. The expected date of confinement is determined using the criteria of the guidelines for obstetrical practice in Japan (2014) in pregnant women.
4. Singleton pregnancy.
5. Written informed consent.

Exclusion Criteria

Attending physician decides to entry inappropriate.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of expression of maternal serum protein and cell-free RNA between pregnant women complicated with and without placental origin of pregnancy disorders.

Secondary Outcome Measures

Name	Time	Method
1. Pathological findings of the placenta.<br>2. Expression of maternal serum protein and cell-free RNA in the maternal blood.<br>3. Expression of protein and gene levels in the placenta. <br>4. Relationship between maternal blood concentration of tadalafil and urine concentration of cGMP.<br>5. Concentration of tadalafil in the cord blood.<br>6. Concentration of cGMP in the cord blood.<br>7. Relationship between maternal blood concentration of tadalafil and perinatal factors.<br>8. Relationship between concentration of tadalafil in the cord blood and perinatal factors.