The elucidation of placental origins of pregnancy disorders.
Not Applicable
Recruiting
- Conditions
- Fetal growth restriction and hypertensive pregnancy disorders
- Registration Number
- JPRN-UMIN000028772
- Lead Sponsor
- Mie university hospital, Department of Obstetrics and Gynecology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 80
Inclusion Criteria
1. Age>=20
2. Gestational age between 20 + 0 and 33 + 6 weeks in pregnant women.
3. The expected date of confinement is determined using the criteria of the guidelines for obstetrical practice in Japan (2014) in pregnant women.
4. Singleton pregnancy.
5. Written informed consent.
Exclusion Criteria
Attending physician decides to entry inappropriate.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of expression of maternal serum protein and cell-free RNA between pregnant women complicated with and without placental origin of pregnancy disorders.
- Secondary Outcome Measures
Name Time Method 1. Pathological findings of the placenta.<br>2. Expression of maternal serum protein and cell-free RNA in the maternal blood.<br>3. Expression of protein and gene levels in the placenta. <br>4. Relationship between maternal blood concentration of tadalafil and urine concentration of cGMP.<br>5. Concentration of tadalafil in the cord blood.<br>6. Concentration of cGMP in the cord blood.<br>7. Relationship between maternal blood concentration of tadalafil and perinatal factors.<br>8. Relationship between concentration of tadalafil in the cord blood and perinatal factors.