Effects of Static Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
- Conditions
- PainHypoxiaHypercapniaApnea
- Interventions
- Other: Voluntary apnoea
- Registration Number
- NCT06150677
- Lead Sponsor
- Centro Universitario La Salle
- Brief Summary
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent static apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- Asymptomatic subjects aged between 18 and 64 years.
- Cardiovascular, respiratory, metabolic, neurological or osteomuscular signs or pathologies.
- History of epilepsy.
- Pregnant.
- Pharmacological treatment.
- Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 4 weeks.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Static apnea at High Lung Volume Voluntary apnoea Participants will remain at rest in the supine position for 6 minutes. Participants in the experimental group will perform intermittent apneas at high lung volume with a density of 30 seconds, followed by a normal breath of 10 seconds (9 cycles of 30s apnea - 10s normal breathing, until completing the 6 minutes).
- Primary Outcome Measures
Name Time Method Pain pressure threshold (PPT) on thumb, anterior tibial and spinous process of C7 before and after intervention (up 30 minutes) PPT is tested on the dorsal base of the distal phalanx of the thumb on the dominant side and on the muscle belly of the tibialis anterior on the dominant side. The region to be pressed is marked with a pen. The patient is instructed to report with the first appearance of the sensation of "discomfort". An ascending ramp of 0.5 kg/cm/s is applied, at the rhythm of a metronome. The measurement is started on the thumb, and alternated with tibia and C7 until 3 measurements of each region are obtained, enough time to give 30 seconds of rest between measurements in the same region. This protocol has demonstrated high inter-observer reliability measuring healthy subjects (ICC = 0.91).
- Secondary Outcome Measures
Name Time Method Pittsburg Sleep Quality Index (PSQI) before intervention (up 5 minutes) 9-item questionnaire on sleep quality in the past month. The scale has a range of scores from 0 to 21. The lower the score, the more favorable for the patient's health.
Global Physical Activity Questionnaire (GPAQ) before intervention (up 5 minutes) 6-item questionnaire on the level of physical activity at work, for commuting and in leisure time. A higher score means higher weekly physical activity
Blood pressure before, during and after intervention (up 10 minutes) Systolic and diastolic blood pressure will be measured before, during and immediately after the procedure using a digital wrist sphygmomanometer.
Oxygen saturation during intervention (up 6 minutes) Oxygen saturation will be measured during the procedure by finger pulse oximetry.
Perceived Stress Scale (PSS) before intervention (up 5 minutes) 14-item questionnaire about their thoughts and feelings in the last month. The scale has a range of scores from 0 to 56. The lower the score, the more favorable for the patient's health.
Heart rate during intervention (up 6 minutes) Heart rate will be measured during the procedure by finger pulse oximetry.
Rate of perceived exertion (RPE) immediately after intervention (up 10 seconds) RPE Borg CR-10 is used to measure how hard your body works during physical activity. It runs from 0 - 10, using numbers to rate how much effort an activity takes.
Trial Locations
- Locations (1)
CSEU LaSalle
🇪🇸Madrid, Spain