CTRI/2026/01/100407尚未招募4 期
Platelet rich plasma (PRP) vs Prolotherapy in knee osteoarthritis: A single-center randomized controlled trial
AIIMS Bibinagar1 个研究点 分布在 1 个国家目标入组 210 人开始时间: 2026年1月16日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- Visual Analog Scale
研究概览
简要总结
Knee Osteoarthritis significantly affects the quality of life and functional ability of individuals. The use of intra-articular Platelet Rich Plasma (PRP) injections has gained considerable attention as a therapeutic option for knee OA. Prolotherapy, an injection-based treatment involving the administration of a proliferative agent, such as dextrose, has been investigated as a non-surgical intervention for knee OA. This trial aims to compare the outcomes of these two procedures on pain and function with conservative management.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 40.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Knee osteoarthritis diagnosed according to American College of Rheumatology criteria
- •Kellegren-Lawerence grades 2 and 3 on x-ray imaging
- •Knee pain for more than 3 months not responding to conservative management.
排除标准
- •Presence of knee effusion
- •Local infection at the injection site
- •Evidence of systemic infection
- •Previous diagnosis of inflammatory arthropathy.
结局指标
主要结局
Visual Analog Scale
时间窗: Before the first injection | 2 weeks, 6 weeks and 3 months after the first injection
次要结局
- Western Ontario and McMaster Universities Osteoarthritis index(Before the first injection)
研究者
Dachepalli Satya Sreekar
All India Institute of Medical Sciences, Bibinagar
研究点 (1)
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