Viral & Host Factors Associated With Hepatitis B Virus-related Hepatocellular Carcinoma

Terminated

• Conditions: Hepatitis C; Hepatobiliary Cancers; Liver Cancer; Hepatitis B; Hepatobiliary Cancers Liver

• Registration Number: NCT00767936
• Lead Sponsor: Stanford University

Brief Summary

Adult liver cancer is the third leading cause of cancer deaths worldwide. The major risk factor for liver cancer is hepatitis B virus (HBV) infection. The purpose of the study is to sequence the HBV genome in patients with chronic HBV infection, and in patients with liver cancer resulting from chronic HBV infection. The goal is to identify mutations in the HBV genome that predisposes these high risk individuals to the development of liver cancer.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2008-03
• Study First Submitted: 2008-10-03
• Study First Submitted QC: 2008-10-06
• Study First Posted: 2008-10-07
• Primary Completion: 2013-03
• Study Completion: 2013-09
• Status Verified: 2016-06
• Last Update Submitted: 2016-06-28
• Last Update Posted: 2016-06-29

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Male
• Target Recruitment: 135

Inclusion Criteria

1. Patients diagnosed with liver cancer based on biopsy or serum AFP level, associated with characteristic hypervascular liver tumors on triphasic spiral CT scan or MRI.

2. Patients with non-cancer liver conditions such as cirrhosis, adenoma, cholangioma, or nodular hyperplasia.

3. Patients with hepatitis B or hepatitis C viral infections not associated with liver cancer.

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Exclusion Criteria

No other patients except those listed above will be recruited. Additionally, patients will be excluded if, upon looking through their medical records, information required for data analysis are missing.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
identify mutations in the hepatitis B virus genome that predisposes these high risk individuals to the development of liver cancer	one time	We will be using blood specimens collected through another protocol

Trial Locations

Locations (1)

Stanford University School of Medicine; 🇺🇸 Stanford, California, United States