NCT00767936终止不适用
Viral and Host Factors Associated With Development of Hepatitis B Virus-related Hepatocellular Carcinoma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- identify mutations in the hepatitis B virus genome that predisposes these high risk individuals to the development of liver cancer
研究概览
简要总结
Adult liver cancer is the third leading cause of cancer deaths worldwide. The major risk factor for liver cancer is hepatitis B virus (HBV) infection. The purpose of the study is to sequence the HBV genome in patients with chronic HBV infection, and in patients with liver cancer resulting from chronic HBV infection. The goal is to identify mutations in the HBV genome that predisposes these high risk individuals to the development of liver cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with liver cancer based on biopsy or serum AFP level, associated with characteristic hypervascular liver tumors on triphasic spiral CT scan or MRI.
- •Patients with non-cancer liver conditions such as cirrhosis, adenoma, cholangioma, or nodular hyperplasia.
- •Patients with hepatitis B or hepatitis C viral infections not associated with liver cancer.
排除标准
- •No other patients except those listed above will be recruited. Additionally, patients will be excluded if, upon looking through their medical records, information required for data analysis are missing.
结局指标
主要结局
identify mutations in the hepatitis B virus genome that predisposes these high risk individuals to the development of liver cancer
时间窗: one time
We will be using blood specimens collected through another protocol
次要结局
未报告次要终点
研究者
研究点 (1)
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