The Effect of β-hydroxy-β-methylbutyrate Supplementation on Physical Capacity and Body Composition in Trained Athletes

Phase 3

Completed

• Conditions: Sport; Supplements; Supplementation

• Registration Number: NCT03028649
• Lead Sponsor: Poznan University of Medical Sciences

Brief Summary

The purpose of this study was to verify the effect of 12-week with β-hydroxy-β-methylbutyrate (HMB) and a placebo (PLA) supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Detailed Description

The effect of HMB supplementation is of great interest in sport. In view of the inconclusive character of the results of the studies conducted to date and of a relatively low number of studies investigating the effectiveness of HMB supplementation over a longer period on a large population of trained athletes, the aim of this study was to verify the effect of 12-week with HMB and a placebo supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2014-02
• Study Completion: 2014-02
• Status Verified: 2017-01
• Study First Submitted: 2017-01-11
• Study First Submitted QC: 2017-01-18
• Last Update Submitted: 2017-01-18
• Study First Posted: 2017-01-23
• Last Update Posted: 2017-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 58

Inclusion Criteria

• written consent to participate,
• male
• a current medical clearance to practice sports,
• training experience: at least 5 years,
• minimum of 6 workout sessions a week (minimum 3 in the practiced sports discipline).

Exclusion Criteria

• current injury,
• any health-related contraindication,
• declared general feeling of being unwell,
• unwilling to follow the study protocol.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Changes of aerobic capacity after HMB supplementation	Baseline and after 12 weeks
Changes of body composition indices after HMB supplementation	Baseline and after 12 weeks	Analysis of the fat mass and fat free mass
Changes of aerobic capacity after placebo treatment	Baseline and after 12 weeks
Changes of creatine kinase and lactate dehydrogenase activity in blood after HMB supplementation	Baseline and after 12 weeks
Changes of testosterone, cortisol and lactate levels in blood after HMB supplementation	Baseline and after 12 weeks
Changes of anaerobic capacity after placebo treatment	Baseline and after 12 weeks
Changes of testosterone, cortisol and lactate levels in blood after placebo treatment	Baseline and after 12 weeks
Changes of body composition indices after placebo treatment	Baseline and after 12 weeks	Analysis of the fat mass and fat free mass
Changes of creatine kinase and lactate dehydrogenase activity in blood after placebo treatment	Baseline and after 12 weeks
Changes of anaerobic capacity after HMB supplementation	Baseline and after 12 weeks

Secondary Outcome Measures

Name	Time	Method
Statistical evaluation of the significance of differences between the changes in body composition (fat mass and fat free mass)	1 year
Statistical evaluation of the significance of differences between the changes in creatine kinase and lactate dehydrogenase activity and testosterone, cortisol and lactate levels in blood	1 year
Statistical evaluation of the significance of differences between the changes in aerobic capacity indices	1 year
Statistical evaluation of the significance of differences between the changes in anaerobic capacity indices	1 year

Trial Locations

Locations (1)

Poznan University of Life Sciences, ul.Wojska Polskiego 31; 🇵🇱 Poznan, Wielkopolska, Poland