Endoscopic and histologic characterization of esophagogastric neojunction after esophagectomy
Not Applicable
Recruiting
- Conditions
- Esophagogastric neojunction characterization after esophagectomyPrevalence of new cardiac epithelium after esophagectomyOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colonCancer - Oesophageal (gullet)
- Registration Number
- ACTRN12616001247460
- Lead Sponsor
- Instituto Portugues de Oncologia de Lisboa Francisco Gentil
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Patients with esophagogastric anastomosis after esophagectomy with gastric pull-up
Exclusion Criteria
Eastern Cooperative Oncology Group (ECOG) performance status > 2
Upper GI endoscopy and/or sedation contraindications
Patients unable to give informed consent
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the prevalence of cardiac type epithelium in the neojunction after esophagectomy (by endoscopic and histological correlation). Histological examination will be performed on biopsy samples collected during endoscopy.[3 months after surgery and if cardiac type epithelium could not be identified the procedure will be repeated at, 6 and 12 months.<br>];To characterize endoscopic and histologically the neojunction (composite primary outcome). The biopsy samples, collected at suspected cardiac mucosa areas and randomly at the anastomosis (4 quadrant biopsies), 2cm above (esophagus) and 2cm below (stomach) the anastomosis will be characterised by hematoxilin-eosin evaluation complemented by immunohistochemistry methods.<br>[3 months after surgery and if cardiac type epithelium could not be identified the procedure will be repeated at, 6 and 12 months.<br>]
- Secondary Outcome Measures
Name Time Method