Continuous infusion versus intermittent dosing of pantoprazole for the prevention of bleeding after endoscopic submucosal dissection : A prospective randomized trial

Not Applicable

Completed

• Conditions: Neoplasms

• Registration Number: KCT0000391
• Lead Sponsor: Pusan National University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

a. gastric adenoma(no limitation in size)

b. early gastric cancer /c no LN involvement and metastasis by abdominal CT (expanded criteria by Gotoda et. al)
? differentiated type
- mucosal cancer without ulcer finding irrespective of tumor size
- mucosal caner with ulcer finding = 3cm
- minute (<500um from muscularis mucosa) submucosal invasive cancer = 3cm
? undifferentiated type
- mucosal cancer without ulcer finding = 2cm

Exclusion Criteria

a. previous history of UGI surgery or vagotomy
b. known hypersensitivity on pantoprazole
c. current use of aspirin, antiplatelet, anticoagulant, NSAIDs, steroid
d. current use of PPI
e. abnormal coagulation profile
f. women either pregnant or at risk of pregnancy
g. lactating women
h. ASA III or IV or severe comorbidity
e. reccured lesion

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
early bleeding after ESD;delayed bleeding after ESD

Secondary Outcome Measures

Name	Time	Method
immediate bleeding during ESD