Regional Anesthesia for Knee Prothesis Surgery

Not Applicable

• Conditions: Total Knee Replacement
• Interventions: Drug: Analgesic nerve blockade (Ropivacaine); Procedure: Total knee replacement surgery.

• Registration Number: NCT02451605
• Lead Sponsor: University of Liege

Brief Summary

Comparison of the analgesics blocks (femoral, adductor canal and sciatic subgluteal nerve) for total replacement knee surgery.

Detailed Description

Adductor canal block shows a beneficial effect for knee surgery. Mainly because he prevent for muscular weakness; adverse effect meet with femoral block and delaying the early active mobilization.

The investigators want to compare the efficacy and safety of this block compared to the femoral and sciatic block.

Study Timeline

• Status Verified: 2015-05
• Study First Submitted: 2015-05-12
• Study First Submitted QC: 2015-05-21
• Last Update Submitted: 2015-05-21
• Study First Posted: 2015-05-22
• Last Update Posted: 2015-05-22
• Study Start: 2015-06
• Primary Completion: 2015-11
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• patients scheduled for total knee replacement surgery.

Exclusion Criteria

• refusal to study,
• coagulation disorder,
• infection at the puncture site,
• preexisting neuropathy,
• allergy to local anesthetics,
• renal or hepatocellular insufficiency,
• context of chronic pain,
• drugs abuse,
• pregnant patient.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Adductor canal blockade	Total knee replacement surgery.	In this group, patient will benefit of an ultrasound guided adductor canal blockade with continuous catheter infusion (initial bolus of 20ml of ropivacaine 0.75% follow with 7ml/hour of ropivacaine 0.2%) as analgesic nerve blockade for for total knee replacement surgery.
Subgluteal sciatic nerve blockade	Total knee replacement surgery.	In this group, patient will benefit of an ultrasound guided subgluteal sciatic nerve blockade with continuous catheter infusion (initial bolus of 20ml of ropivacaine 0.75% follow with 7ml/hour of ropivacaine 0.2%) as analgesic nerve blockade for total knee replacement surgery.
Femoral nerve blockade	Analgesic nerve blockade (Ropivacaine)	In this group, patient will benefit of an ultrasound guided femoral nerve blockade with continuous catheter infusion as (initial bolus of 20ml of ropivacaine 0.75% follow with 7ml/hour of ropivacaine 0.2%) as analgesic nerve blockade for total knee replacement surgery.
Femoral nerve blockade	Total knee replacement surgery.	In this group, patient will benefit of an ultrasound guided femoral nerve blockade with continuous catheter infusion as (initial bolus of 20ml of ropivacaine 0.75% follow with 7ml/hour of ropivacaine 0.2%) as analgesic nerve blockade for total knee replacement surgery.
Adductor canal blockade	Analgesic nerve blockade (Ropivacaine)	In this group, patient will benefit of an ultrasound guided adductor canal blockade with continuous catheter infusion (initial bolus of 20ml of ropivacaine 0.75% follow with 7ml/hour of ropivacaine 0.2%) as analgesic nerve blockade for for total knee replacement surgery.
Subgluteal sciatic nerve blockade	Analgesic nerve blockade (Ropivacaine)	In this group, patient will benefit of an ultrasound guided subgluteal sciatic nerve blockade with continuous catheter infusion (initial bolus of 20ml of ropivacaine 0.75% follow with 7ml/hour of ropivacaine 0.2%) as analgesic nerve blockade for total knee replacement surgery.

Primary Outcome Measures

Name	Time	Method
Pain measurement with numeric pain scale : from 0 to 10 (maximal pain) in rest condition	up to day 7	Pain assessment and evolution in postoperative period (passive condition)
Pain measurement with numeric pain scale (from 0 to 10) during active motorized mobilization (Kinetic)	up to day 7	Pain assessment and evolution in postoperative period (active condition)

Secondary Outcome Measures

Name	Time	Method
Opioid consumption	up to 48 hours	doses of piritramid (synthetic opioid) administrated with patient control rescue analgesia device.
Patient satisfaction	at day 1	Questionnaire of patient felling and satisfaction. Choice within gradual felling : bad, middle, good, excellent
Postintervention nausea vomiting	at hour 0, at hours 6, at day 1	question : present or not

Trial Locations

Locations (1)

University og Liege, University Hospital; 🇧🇪 Liege, Belgium