ISRCTN30952488已完成4 期
A series of randomised controlled N-of 1 trials in patients who have discontinued or are considering discontinuing statin use due to muscle-related symptoms to assess if atorvastatin treatment causes more muscle symptoms than placebo.
ondon School of Hygiene and Tropical Medicine0 个研究点目标入组 200 人开始时间: 2016年5月12日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 200
研究概览
简要总结
2017 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29197834 protocol 2021 Results article in https://doi.org/10.1136/bmj.n135 results (added 25/02/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33709907/ results (added 15/03/2021) 2019 Results article in https://doi.org/10.3390/healthcare7040134 (added 14/06/2023)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Adults (aged 16 and over)
- •2. Prescribed statin treatment in the last 3 years
- •3. Stopped OR considering stopping statin treatment due to muscle symptoms
- •4. Provided fully informed consent
排除标准
- •1. Any previously documented serum alanine aminotransferase (ALT) levels at or above three times the upper limit of normal
- •2. Have persistent, generalised, unexplained muscle pain (whether associated or not with statin use) and have creatinine kinase (CK) levels greater than 5 times the upper limit of normal
- •3. Should not be using atorvastatin 20mg daily in the opinion of the general practitioner
研究者
相似试验
已完成
不适用
A randomized controlled trial of an empowerment intervention for female adolescents with diabetes.Type 1 diabetesNutritional, Metabolic, EndocrineDiabetesISRCTN57528404Karolinska Institute / Södersjukhuset100
已完成
不适用
Prospective randomised multicentre trial investigating liver preservation with Histidine-Tryptophan-Ketoglutarate (HTK) by simple aortic perfusion in comparison to aortic perfusion plus ex situ arterial flushingISRCTN78500982Johannes Gutenberg University of Mainz (Germany)242
进行中（未招募）
不适用
The BASIL-3 Trial: Balloon vs. Stenting in Severe Ischaemia of the Leg-3Severe limb ischaemia due to femoro-popliteal diseaseCirculatory SystemPeripheral vascular disease, unspecifiedISRCTN14469736niversity of Birmingham481
已完成
3 期
Speed of Increasing milk Feeds TrialISRCTN76463425niversity of Oxford (UK)2,804
已完成
不适用
The effect of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancerChemotherapy-induced nausea and vomitingSigns and SymptomsNausea and vomitingISRCTN13287728Beijing Municipal Administration of Hospitals136