Effects of Multiple Concussions in Retired NHL Players
- Conditions
- Cognitive DeficitsProprioceptive Disorders
- Interventions
- Other: Sensory Organization TestGenetic: BiomarkersOther: Conners' Adult ADHD Rating Scale (CAARS)Other: Depression ScaleOther: Cognitive Assessment
- Registration Number
- NCT02746523
- Lead Sponsor
- New York Institute of Technology
- Brief Summary
To investigate long term affects of multiple concussions on the cognition, balance, proprioception, and biomarkers in retired National Hockey League players
- Detailed Description
This research study will collect data for each subject in one single visit. During the visit the subject will be asked to consent to the study which is estimated to take approximately 10 minutes. A medical history will be obtained, taking approximately 15 minutes. Blood, urine, and cheek swabs will be collected for approximately 15 minutes. The PHQ-9, Becks Depression Inventory, Connors Adult ADHD Rating Scale (CAARS™), and Montreal Cognitive Assessment (MoCA) will be administered, these assessments combined are estimated to take 50 minutes. Lastly, patients will be asked to complete a Sensory Organization Test (SOT) which takes approximately 15 minutes. There are only licensed health professionals working on this project that will respect your privacy and conduct this trial following all HIPPA and clinical research guidelines.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Male
- Target Recruitment
- 6
- Retired professional NHL player
- History or reported concussion and concussion like symptoms
- Any neurological condition
- Non sport related head trauma
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Case / Retired NHL Players Depression Scale All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers Case / Retired NHL Players Cognitive Assessment All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers Age Matched Controls Sensory Organization Test All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers Case / Retired NHL Players Sensory Organization Test All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers Case / Retired NHL Players Biomarkers All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers Case / Retired NHL Players Conners' Adult ADHD Rating Scale (CAARS) All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers Age Matched Controls Biomarkers All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers Age Matched Controls Cognitive Assessment All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers Age Matched Controls Conners' Adult ADHD Rating Scale (CAARS) All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers Age Matched Controls Depression Scale All interventions for this group are described below: Sensory Organization Test (SOT): Balance and proprioception test Connor's Adult ADHD Rating Scale (CAARS): A computer based questionnaire used to measure the presence of adult attention deficit hyperactivity disorder. Beck's Depression Inventory: A 21 question multiple choice self report measuring the severity of depression Patient Health Questionnaire 9 (PHQ-9): Self administered screening questionnaire for mental health disorders Montreal Cognitive Assessment (MoCA): A validated screening tool to assess cognitive mild impairment Blood/Urine/Saliva Biomarker analysis: These samples will be analyzed for relevant biomarkers
- Primary Outcome Measures
Name Time Method Cognition assessed with the Montreal Cognitive Assessment Scale 10 minutes Montreal Cognitive Assessment Scale
- Secondary Outcome Measures
Name Time Method Human Interleukin-6 (IL-6) 5 Minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed biomarkers Marker type: Inflammation
Patient Health Questionnaire 9 (PHQ-9) 5 minutes Self administered screening and diagnostic questionnaire for mental health disorders
S-100B Calcium binding protein 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Blood brain barrier damage
Total Tau Protein (tTAU) 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Traumatic brain injury
Adult Attention Deficit assessed with the Connors' Adult Attention Deficit Disorder Rating Scale 10 minutes Connors' Adult Attention Deficit Disorder Rating Scale
Interleukin 7 (IL-7) 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed biomarkers Marker Type: Inflammation
8-iso-Prostaglandin F2a 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: oxidative stress on lipids
Dityrosine 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Oxidative Stress on protein
Proprioception/Postural Stability assessed with the Sensory Organization Test 15 minutes Sensory Organization Test
MicroRNA miR132 5 minutes Blood (20 cc), Urine (40 cc), Saliva (5 cc) Total volume for all proposed Marker Type: MicroRNA
Brain derived neurotrophic factor (BDNF) 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Inflammation
Beck's Depression Inventory 10 minutes A 21 question multiple choice self report inventory measuring the severity of depression
3-nitrotyrosine 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Oxidative stress on lipids
Apolipoprotein E-4 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Traumatic brain injury
MicroRNA miR183 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: MicroRNA
Amyloid beta 40 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Neurodegeneration
Eco-Rna Species 5 minutes Blood (20 cc), Urine (40 cc),Saliva (5 cc): Total volume for all proposed Marker Type: Exo-RNA
Human 8-hydroxy-2' -deoxyguanosine (8-OHdG) 5 minutes Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Oxidative stress on DNA
Complement Component 3 B (C3b) 5 minutes Blood (20 cc), Urine (40 cc), Saliva (5 cc): Total volume for all proposed Marker Type: Complement system
Trial Locations
- Locations (1)
NYIT
🇺🇸Old Westbury, New York, United States