A Pilot Study Investigating Differences in Muscle Metabolic Function in Individuals Aged 65-75 Years With Different Vitamin D Status Before and After 7-days of Aerobic Training
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Muscle VO2 consumption
研究概览
简要总结
This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 75 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •65-75 years of age
排除标准
- •Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise.
- •Uncontrolled diabetes or hypertension.
- •History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity
- •History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months
- •Have a diagnosis of osteoporosis (as determined by DXA)
- •Participated in a resistance or aerobic training program in the last 3 months
- •Engage in more than 1 hr/week of vigorous activity
- •Body mass index >29
- •On hormone replacement therapy
研究组 & 干预措施
Low 25(OH)D
We will recruit individuals with low 25(OH)D (<30ng/mL).
干预措施: 7 continuous days of aerobic training (Other)
High 25(OH)D
We will recruit individuals with higher 25(OH)D (at least 20ng/mL units higher then that of the "low 25(OH)D group).
干预措施: 7 continuous days of aerobic training (Other)
结局指标
主要结局
Muscle VO2 consumption
时间窗: Up to 3 months
The objective is to examine the difference in gastrocnemius VO2 consumption in individuals that either have normal-high or low 25(OH)D and are undergoing 7-days of a treadmill training program.
次要结局
未报告次要终点
研究者
David Travis Thomas
Ph.D., RD, CSSD, CSCS
University of Kentucky