Prediction and Prevention of Preeclampsia by First Trimester Ultrasound
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Preeclampsia
- Sponsor
- Norwegian University of Science and Technology
- Enrollment
- 602
- Locations
- 1
- Primary Endpoint
- Development of preeclampsia
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to determine whether the Fetal Medicine Foundation algorithm for individual risk calculation for preeclampsia (PE) and pregnancy induced hypertension (PIH) is suitable to identify women in high risk of developing these diseases in a Norwegian population.
Detailed Description
It has been shown that low dose acetylsalicylic acid (ASA) in pregnancy reduces adverse outcome of pregnancy in women that have high risk of developing preeclampsia (PE). It is a challenge for the clinician to identify the high risk women. Doppler blood flow measurements in uterine arteries in second trimester have been shown useful to predict the development of the disease but prophylactic treatment with ASA from this point in pregnancy has not been proven effective. Fetal Medical Foundation has developed an algorithm that calculates individual risks for PE/ PIH based on Doppler blood flow measurements and anamnestic information.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Nulliparous
- •Para 1+ with previous preeclampsia or gestational hypertension
- •last menstrual period (LMP) pregnancy length at inclusion \< 13 weeks
- •Residence in Trondheim + 8 surrounding municipalities
Exclusion Criteria
- •Pregnancy length \> 13+6 weeks (CRL \> 85 mm)
- •Missed abortion
- •Fetal anomaly
Outcomes
Primary Outcomes
Development of preeclampsia
Time Frame: september 2012
Onset time of preeclampsia
Time Frame: September 2012
Secondary Outcomes
- Gestational age at delivery(September 2012)
- Number of induction of deliveries due to preeclampsia(September 2010)
- Maternal morbidity(September 2012)
- Perinatal morbidity(September 2012)
- Number of instrumental deliveries due to preeclampsia(September 2012)