Prediction and Prevention of Preeclampsia by First Trimester Ultrasound
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 602
- 试验地点
- 1
- 主要终点
- Development of preeclampsia
研究概览
简要总结
The purpose of this study is to determine whether the Fetal Medicine Foundation algorithm for individual risk calculation for preeclampsia (PE) and pregnancy induced hypertension (PIH) is suitable to identify women in high risk of developing these diseases in a Norwegian population.
详细描述
It has been shown that low dose acetylsalicylic acid (ASA) in pregnancy reduces adverse outcome of pregnancy in women that have high risk of developing preeclampsia (PE). It is a challenge for the clinician to identify the high risk women. Doppler blood flow measurements in uterine arteries in second trimester have been shown useful to predict the development of the disease but prophylactic treatment with ASA from this point in pregnancy has not been proven effective. Fetal Medical Foundation has developed an algorithm that calculates individual risks for PE/ PIH based on Doppler blood flow measurements and anamnestic information.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Nulliparous
- •Para 1+ with previous preeclampsia or gestational hypertension
- •last menstrual period (LMP) pregnancy length at inclusion < 13 weeks
- •Residence in Trondheim + 8 surrounding municipalities
排除标准
- •Pregnancy length > 13+6 weeks (CRL > 85 mm)
- •Missed abortion
- •Fetal anomaly
结局指标
主要结局
Development of preeclampsia
时间窗: september 2012
Onset time of preeclampsia
时间窗: September 2012
次要结局
- Gestational age at delivery(September 2012)
- Number of induction of deliveries due to preeclampsia(September 2010)
- Maternal morbidity(September 2012)
- Perinatal morbidity(September 2012)
- Number of instrumental deliveries due to preeclampsia(September 2012)