Addition of Neostigmine to Levobupivacaine

Not Applicable

Completed

• Conditions: Spermatic Cord Block
• Interventions: Drug: Control Test; Drug: Neostigmine

• Registration Number: NCT04492319
• Lead Sponsor: Cairo University

Brief Summary

Using the spermatic cord block has been of great advantage, as it has been cost saving, efficient technique whether used inon its own or combination with a sedative or . Furthermore, it provides minimal cardiac risks, early case ambulation, satisfactory postoperative pain control, as well as a reduced hospital stay and cost. one of the major drawbacks of spermatic cord block is being a single injection technique, leading to a short postoperative analgesia duration. So, to overcome this flaw some adjuvants were proven to prolong the analgesia duration as neostigmine.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-03
• Study First Submitted QC: 2020-07-28
• Study First Posted: 2020-07-30
• Study Start: 2020-09-29
• Primary Completion: 2023-11-23
• Study Completion: 2023-12-20
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-05
• Last Update Posted: 2024-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 112

Inclusion Criteria

• Patients aged from 20 to 45 years.
• American Society of Anesthesiologists I-II.
• Undergoing Testicular Sperm Extraction Surgery.
• BMI from 18.5 to 40 kg/m2

Exclusion Criteria

• Patient refusal
• Contraindications to regional anesthesia (bleeding disorders e.g. international normalized ratio >1.5, Prothrombin Concentration <70%, platelet count<100 × 109, use of any anti-coagulants, local infection, etc.).
• Known allergy to local anesthetics.
• ASA III-IV.
• Patients aged less than 18 or more than 60.
• Body mass index >35.:

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	Control Test	-
neostigmine group	Neostigmine	-

Primary Outcome Measures

Name	Time	Method
Time from end of surgery to the first postoperative analgesic request	UP TO 24 HOURE	(duration of the block).

Secondary Outcome Measures

Name	Time	Method
spermatic cord block time	UP TO 1 HOURE	The mean time needed to perform spermatic cord block
visual analog scale	UP TO 24 HOURE	visual analog scale ; 0 is bad / 10: is good
Incidence of complications	up to 24 hours	complications
Postoperative analgesic use	up to 24 hours	amount of Acetaminophen used postoperative

Trial Locations

Locations (1)

Faculty of Medicine, Cairo University.; 🇪🇬 Cairo, Egypt