The Effect of Addition of Neostigmine to Levobupivacaine in Male Patients Receiving Ultrasound Guided Spermatic Cord Block for Postoperative Analgesia in Testicular Sperm Extraction Surgery:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- Time from end of surgery to the first postoperative analgesic request
研究概览
简要总结
Using the spermatic cord block has been of great advantage, as it has been cost saving, efficient technique whether used inon its own or combination with a sedative or . Furthermore, it provides minimal cardiac risks, early case ambulation, satisfactory postoperative pain control, as well as a reduced hospital stay and cost. one of the major drawbacks of spermatic cord block is being a single injection technique, leading to a short postoperative analgesia duration. So, to overcome this flaw some adjuvants were proven to prolong the analgesia duration as neostigmine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Patients aged from 20 to 45 years.
- •American Society of Anesthesiologists I-II.
- •Undergoing Testicular Sperm Extraction Surgery.
- •BMI from 18.5 to 40 kg/m2
排除标准
- •Patient refusal
- •Contraindications to regional anesthesia (bleeding disorders e.g. international normalized ratio >1.5, Prothrombin Concentration <70%, platelet count<100 × 109, use of any anti-coagulants, local infection, etc.).
- •Known allergy to local anesthetics.
- •ASA III-IV.
- •Patients aged less than 18 or more than
- •Body mass index >35.:
研究组 & 干预措施
control group
干预措施: Control Test (Drug)
neostigmine group
干预措施: Neostigmine (Drug)
结局指标
主要结局
Time from end of surgery to the first postoperative analgesic request
时间窗: UP TO 24 HOURE
(duration of the block).
次要结局
- spermatic cord block time(UP TO 1 HOURE)
- visual analog scale(UP TO 24 HOURE)
- Incidence of complications(up to 24 hours)
- Postoperative analgesic use(up to 24 hours)
研究者
Amr Samir Wahdan
Lecturer of Anesthesia, Pain management and Surgical ICU
Cairo University