The bilious bowel: the relation between bile and bowel in development of biliary atresia and liver fibrosis. An explorative study
Completed
- Conditions
- liver fibrosis - scarring of the liver100198061000007310019654
- Registration Number
- NL-OMON44888
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
children with hepatobiliary disease necessitating surgery
Exclusion Criteria
Adults, congenital bowel defects or abdominal wall defects, extreme prematurity/very low birth weigth
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Clearance of jaundice, transplantation-free survival</p><br>
- Secondary Outcome Measures
Name Time Method <p>Gut microbiota in faeces, serum levels of Zonulin and tight<br /><br>junction/translocation markers e.g. ZO-1, Claudin-1, 2 and 3,<br /><br>Lipopolysaccharide Binding Protein (LBP) and CD14. Secondary end points:<br /><br>histological assessment of both the tight junction complex in the small bowel<br /><br>as well as liver fibrosis as present in routine clinical pre- or preoperative<br /><br>liver biopsies or as assessed using Fibroscan and/or APRI</p><br>