NCT00199537已完成不适用
Bone Loss in Men on Androgen Blockade as Adjuvant Therapy for Prostate Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
研究概览
简要总结
Patients with advanced prostate cancer undergoing adjuvant treatment with androgen blockade will be followed over a 1 year interval to assess the effects of this treatment on bone metabolism. It is expected that men undergoing androgen blockade will experience accelerated bone loss.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Age of 40 years or greater
- •Diagnosis of advanced prostate cancer (ie: prostate-specific antigen [PSA] less than 25 ug/L and undergoing continued treatment with leuteinizing hormone-releasing hormone [LHRH] therapy)
- •Willing and able to consent
排除标准
- •Metastatic disease to bone
- •Medications affecting bone turnover (bisphosphonate, steroids, anticonvulsant)
- •Renal failure (serum creatinine > 200 umol/L)
- •Co-morbidity factors affecting bone density (ie: Paget's, rheumatoid arthritis)
- •Factors affecting ability to perform the bone density tests using femoral head measurements (ie: bilateral hip arthroplasty)
- •Cancer other than skin, except when, in the investigators' opinion, it is determined to be appropriate and not adversely affect the outcome of the trial
- •Gastrointestinal (GI) pathology (eg. malabsorption syndrome)
- •Parathyroid disease
研究者
研究点 (1)
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