Optimising pain relief after knee joint replacement surgery at Counties Manukau Health; We compare two methods of local anaesthesia (numbing medicine) administration to reduce pain after knee replacement surgery.

Phase 4

Recruiting

• Conditions: Pain relief after Total Knee Arthroplasty; Anaesthesiology - Pain management; Surgery - Other surgery; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12619000221156
• Lead Sponsor: Counties Manukau Health, Middlemore Hospital Research Office

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-02-14
• Last Update Posted: 3 March 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

We aim to enrol patients undergoing primary TKA in our institution prior to the day of surgery in the preadmission clinic or on the day of surgery at the time of surgical and anaesthetic consent. Adequate time for patient questions and a plain language explanation sheet will be provided to aid patient consent. The study will be completed at Middlemore Hospital and Manukau Surgical Centre.

Exclusion Criteria

•Refusal or inability to consent.
•Analgesic technique involving epidural or peripheral nerve blockade (single shot or continuous techniques)
•Nerve catheter placed outside accepted range (distal to femoral triangle down to the adductor canal)
•Allergies to medication used in the study or its constituents
•Significant kidney and liver dysfunction (CrCl < 30mls/min, AST/ALT >2x upper limit of normal)
•Surgical procedure performed outside of Counties Manukau Health facilities.
•Failure to site adductor canal catheter in the appropriate location.
•Patients on >30mg/day of oral morphine equivalent for any reason.
•Patients outside the specified age range of 18-80 years.
•Patients at extremes of weight e.g.<50kg or >150kg
•If surgical team do not wish to take part or give individually tailored treatment that violate study protocol.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total oral morphine consumption over 48 hours after starting study infusion in PACU. Conversion to daily oral morphine equivalence will be calculated based on the methods prescribed by the Faculty of Pain Medicine of the Australian and New Zealand College of Anaesthetists<br><br>We will gather this information from paper-based and electronic hospital records.[24, 48 hours after commencement of infusion in post-operative anaesthetic care unit (PACU)<br><br>The primary outcome measured at 48 hours after commencing infusion in PACU. <br>]