Cerebral Haemorrhage associated Inflammation: a PET/MRI Study

Radboudumc0 个研究点目标入组 10 人开始时间: 待定最近更新: 2024年2月28日

试验速览

暂无简介。

•1.Age = 18 years;
•2.Supratentorial non-traumatic ICH confirmed by CT, without a confirmed causative lesion on admission CT-angiography or other known underlying lesion;
•3.Minimal haemorrhage volume of 10mL;
•4.Inclusion within 24 hours after symptom onset;
•5.Patient’s or legal representative’s informed consent.

•1.Severe infection at admission, requiring antibiotic treatment;
•2.Use of immunosuppressive or immune-modulating therapy at admission (see appendix A );
•3.Pre-stroke modified Rankin Scale score = 3
•4.Severe ICH, unlikely to survive the first 72 hours (defined as Glasgow Coma Scale score < 6 at time of consent);
•5.Pregnancy or breast-feeding;
•6.Standard contraindications to MRI;
•7.Administration of a radionuclide within 10 physical half-lives prior to study enrolment.
•8.Known prior allergic reaction to gadolinium contrast or one of the constituents of its solution for administration;
•9.Severe renal impairment (eGFR <30ml/min/1.73m);
•10.Planned neurosurgical haematoma evacuation.

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