A study assessing the usefulness of measuring platelet function after cardiac surgery

Not Applicable

Completed

Conditions: Coronary Artery Disease / Coronary Artery Bypass Graft / Antiplatelet medications
Circulatory System
Atherosclerotic heart disease

Registration Number: ISRCTN43298975

Lead Sponsor: Wolverhampton Coronary Aftercare Support Group (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 84

Inclusion Criteria

1. Male and female patients aged 18 years and over
2. Patient who can give informed consent
3. Patients undergoing first time coronary artery bypass graft (CABG) using cardiopulmonary bypass

Exclusion Criteria

1. Patients who are unable to consent
2. Patients less than 18 years old
3. Severe liver or renal dysfunction (Altered Liver Function Test, Creatinine >200)
4. Patients who are already part of another study
5. Patient with known bleeding diathesis

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Current primary outcome measures as of 01/04/2014:<br>The primary endpoint was to correlate excessive post-operative bleeding defined as blood loss in excess of 2.5 ml/kg/hr in the immediate 3 hours, with the presence of platelet dysfunction as assessed by Multiplate® and TEG. <br><br>Previous primary outcome measures:<br>The primary endpoint is to correlate excessive postoperative bleeding defined as a blood loss of 2.5 ml/kg/hr in the immediate 3 hours and the total bleeding within the first 8 hours post-surgery, with the presence of platelet dysfunction as measured by the Multiplate®.

Secondary Outcome Measures

Name	Time	Method
Current secondary outcome measures as of 01/04/2014:<br>1. Transfusion requirements for blood and blood products<br>2. Overall blood loss within 8 hours of surgery<br>3. Postoperative complications<br>4. Intensive care unit (ICU) length of stay<br>5. Hospital length of stay<br><br>Previous secondary outcome measures:<br>1. Transfusion requirements for blood and blood products<br>2. Comparison of Multiplate® and TEG<br>3. Postoperative complications<br>4. ICU length of stay<br>5. Hospital length of stay