ACTRN12613000524796
Not yet recruiting
未知
In primary carers of Alzheimer’s Disease patients does the interactive impact of chronic stress and malnourishment increase the risk of telomere, genome and epigenome instability, compared with non-carers.
Commonwealth Scientific and Industrial Research Organisation (CSIRO) Preventative Health Flagship0 sites100 target enrollmentMay 13, 2013
ConditionsDNA damage and telomere instabilityThe molecular impact of psychological stressAssociation of nutritional biomarkers with stress and DNA stability.Diet and Nutrition - Other diet and nutrition disordersOther - Research that is not of generic health relevance and not applicable to specific health categories listed above
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- DNA damage and telomere instability
- Sponsor
- Commonwealth Scientific and Industrial Research Organisation (CSIRO) Preventative Health Flagship
- Enrollment
- 100
- Status
- Not yet recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Inclusion criteria \- Carers: Primary carer of a person diagnosed with Alzheimer’s Disease (AD); \=1 year since partner’s AD diagnosis; Male or female; Aged 65\-90 years
- •Inclusion criteria \- Control Group: Male or female; Aged 65\-90 years.
Exclusion Criteria
- •Exclusion criteria \- Carers: Diagnosed with a neurodegenerative condition, cognitive impairment or chronic illness requiring ongoing medical treatment; Undergoing chemotherapy/radiotherapy for cancer treatment; Supplementing with above RDI intakes of micronutrients associated with genome maintenance (eg. folate, vitamin B12\); Consuming more than 3 standard alcoholic drinks/day; Smoker (5 or more cigarettes/day).
- •Exclusion criteria \- Control Group: Carer for a family member with a serious chronic illness/condition, living in the home; Diagnosed with a neurodegenerative condition, cognitive impairment or chronic illness requiring ongoing medical treatment; Undergoing chemotherapy/radiotherapy for cancer treatment; Supplementing with above RDI intakes of micronutrients associated with genome maintenance (eg. folate, vitamin B12\); Consuming more than 3 standard alcoholic drinks/day; Smoker (5 or more cigarettes/day).
Outcomes
Primary Outcomes
Not specified
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